rad50 rad50 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rad50provided by FlyBase
Official Full Name: rad50provided by FlyBase
Primary source: FLYBASE:FBgn0034728
Locus tag: Dmel_CG6339
See related: AllianceGenome:FB:FBgn0034728
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 6339; CG6339; Dmel\CG6339; Dmrad50; dRad50; Rad-50; Rad50; RAD50
Summary: Predicted to enable G-quadruplex DNA binding activity; double-stranded telomeric DNA binding activity; and single-stranded telomeric DNA binding activity. Involved in double-strand break repair; protein localization; and telomere maintenance via recombination. Located in condensed chromosome and nucleus. Part of Mre11 complex. Is expressed in several structures, including adult head; anlage in statu nascendi; central brain anlage; central brain anlage in statu nascendi; and ganglia. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22421013..22425482)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18308518..18312987)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables G-quadruplex DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables double-stranded telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization involved in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Mre11 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mre11 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Mre11 complex	IEA Inferred from Electronic Annotation more info
part_of Mre11 complex	TAS Traceable Author Statement more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

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