dve defective proventriculus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dveprovided by FlyBase
Official Full Name: defective proventriculusprovided by FlyBase
Primary source: FLYBASE:FBgn0020307
Locus tag: Dmel_CG5799
See related: AllianceGenome:FB:FBgn0020307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5799; dep; Dmel\CG5799; Dve; DVE; Dve-s; l(2)01738; SATB1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including copper ion import; imaginal disc-derived appendage morphogenesis; and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in several structures, including embryonic/larval midgut cell; ganglia; gut section; head epidermis primordium; and imaginal disc. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB1 (SATB homeobox 1) and SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 58D2-58D2; 2-99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22243963..22286469)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18131468..18173974)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fecundity is optimized by levels of nutrient signal-dependent expression of Dve and EcR in Drosophila male accessory gland.
Title: Fecundity is optimized by levels of nutrient signal-dependent expression of Dve and EcR in Drosophila male accessory gland.
Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes.
Title: Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes.
The relationship between Sal, Dve, and Iro-C in wing vein specification is quite similar to that in ommatidial cell-type specification. Our results provide information about the conserved function of dve regulatory motifs in cell differentiation.
Title: Spalt-mediated dve repression is a critical regulatory motif and coordinates with Iroquois complex in Drosophila vein formation.
Ectopic antenna formation in heads with dve mutant clones was associated with ectopic Dll expression and endogenous Hth expression in the vertex region.
Title: A vertex specific dorsal selector Dve represses the ventral appendage identity in Drosophila head.
Male accessory gland secondary cells are crucial for male fecundity, and Dve activity is required for their survival.
Title: The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila.
The homeobox gene defective proventriculus (dve) is expressed in the midgut, and two transcripts, type A and type B, have been identified
Title: Spatial and temporal requirement of defective proventriculus activity during Drosophila midgut development.
AP-2 and defective proventriculus regulate Serrate and Delta expressiion in the tarsus of Drosophila melanogaster.
Title: dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.
Dve suppresses the potential joint-forming activity, and that Notch signaling represses Dve expression to form joints.
Title: Notch signaling relieves the joint-suppressive activity of Defective proventriculus in the Drosophila leg.
Defective proventriculus (Dve), mediates the refinement of wg expression in both the wing disc and embryonic proventriculus, where dve expression requires Wg signaling.
Title: Refinement of wingless expression by a wingless- and notch-responsive homeodomain protein, defective proventriculus.
These results indicate that EGFR signaling is crucial for dve expression in the ventral ectoderm and is required in the middle midgut where it cooperates with Dpp signaling.
Title: Differential requirement of EGFR signaling for the expression of defective proventriculus gene in the Drosophila endoderm and ectoderm.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0005 (e-PCR)
- UniSTS:60586

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in copper ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive structure development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: defective proventriculus

Names: CG5799-PA; CG5799-PB; compass; dve-PA; dve-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22243963..22286469

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057894.4 → NP_477242.1 defective proventriculus, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477242.1

Status: REVIEWED

UniProtKB/TrEMBL

O76143, Q9W268

Related

FBpp0071689

Conserved Domains (3) summary

smart00389
Location:556 → 623

HOX; Homeodomain

cd11585
Location:252 → 358

SATB1_N; N-terminal domain of SATB1 and similar proteins

pfam09184
Location:644 → 778

PPP4R2; PPP4R2
NM_057893.5 → NP_477241.2 defective proventriculus, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477241.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8MLT6, Q8MQP8

Related

FBpp0089292

Conserved Domains (3) summary

smart00389
Location:312 → 379

HOX; Homeodomain

cd11585
Location:8 → 114

SATB1_N; N-terminal domain of SATB1 and similar proteins

pfam09184
Location:400 → 534

PPP4R2; PPP4R2