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B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Homo sapiens (human) ]

Gene ID: 374907, updated on 5-Mar-2024

Summary

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Official Symbol
B3GNT8provided by HGNC
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by HGNC
Primary source
HGNC:HGNC:24139
See related
Ensembl:ENSG00000177191 MIM:615357; AllianceGenome:HGNC:24139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B3GALT7; BGALT15; beta3Gn-T8
Summary
Enables protein N-acetylglucosaminyltransferase activity. Involved in poly-N-acetyllactosamine biosynthetic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine (RPKM 4.8), duodenum (RPKM 4.7) and 15 other tissues See more
Orthologs
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Genomic context

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See B3GNT8 in Genome Data Viewer
Location:
19q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41425359..41428730, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44246583..44249963, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41931264..41934635, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41892254-41892432 Neighboring gene exosome component 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903234-41903906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903907-41904578 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41912476-41913430 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:41913431-41914386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10667 Neighboring gene VISTA enhancer hs1948 Neighboring gene distal membrane arm assembly component 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14682 Neighboring gene glutamate rich 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901. Jiang Z, et al. Oncol Rep, 2016 Sep. PMID 27459970
  2. Knockdown of β3GnT8 reverses 5-fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine-type N-glycans. Shen L, et al. Int J Oncol, 2014 Dec. PMID 25269761
  3. High expression of β3GnT8 is associated with the metastatic potential of human glioma. Liu J, et al. Int J Mol Med, 2014 Jun. PMID 24715095, Free PMC Article
  4. β3GnT8 regulates laryngeal carcinoma cell proliferation via targeting MMPs/TIMPs and TGF-β1. Hua D, et al. Asian Pac J Cancer Prev, 2012. PMID 22901175
  5. Down-regulation of β-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer. Liu Z, et al. Mol Med Rep, 2011 May-Jun. PMID 21468598

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nglycosylation and receptor tyrosine kinase signaling affect claudin3 levels in colorectal cancer cells.
    Title: N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
  2. These results revealed that b3GnT8 may play a key role in the development of oxaliplatin resistance in colon cancer cells possibly through the alteration of the glycosylation of integrin beta1. These findings may be valuable for overcoming drug resistance in colon cancer
    Title: β3GnT8 regulates oxaliplatin resistance by altering integrin β1 glycosylation in colon cancer cells.
  3. Cjun plays a significant role in regulating the expression of beta3GnT8 in the SGC7901 cell line.
    Title: Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901.
  4. Study shows that beta3GnT8 is involved in the regulation of CD147 N-glycosylation and further influences MMP-2 expression in tumor cells suggesting that it may play an important role in the CD147 signaling as an upstream modulator of MMP-2 in tumor cells.
    Title: β3GnT8 plays an important role in CD147 signal transduction as an upstream modulator of MMP production in tumor cells.
  5. In conclusion, the alteration of b3GnT8 in colorectal cancer cells correlates with tumor sensitivity to the chemotherapeutic drug and has significant implication for the development of new treatment strategies.
    Title: Knockdown of β3GnT8 reverses 5-fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine-type N-glycans.
  6. The results demonstrated a critical role of beta3GnT8 in the metastatic potential of glioma cells, indicating that manipulating beta3GnT8 expression may have therapeutic potential for the treatment of malignant glioma.
    Title: High expression of β3GnT8 is associated with the metastatic potential of human glioma.
  7. we suggest that beta3GnT8 plays a key role in the metastasis of colorectal cancer cells by altering the beta1,6-branched polylactosamine sugars of CD147.
    Title: β3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147.
  8. High beta3Gn-T8 expression is associated with laryngeal carcinoma.
    Title: β3GnT8 regulates laryngeal carcinoma cell proliferation via targeting MMPs/TIMPs and TGF-β1.
  9. The down-regulation of beta3Gn-T8 caused significant inhibition of tumor cell growth in vitro.
    Title: Down-regulation of β-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer.
  10. These results reveal a new mechanism by which beta3Gn-T8 can regulate MMP-2 and TIMP-2.
    Title: Regulation of MMP-2 expression and activity by β-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in O-glycan processing TAS
Traceable Author Statement
more info
  
involved_in poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly-N-acetyllactosamine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Names
BGnT-8
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7
beta galactosyltransferase BGALT15
beta-1,3-Gn-T8
beta-1,3-N-acetylglucosaminyltransferase 8
beta1,3-N-acetylglucosaminyltransferase 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385648.2 → NP_001372577.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC011462
    Consensus CDS
    CCDS12582.1
    UniProtKB/Swiss-Prot
    Q7Z7M8
    Related
    ENSP00000510371.1, ENST00000691102.1
    Conserved Domains (1) summary
    cl21608
    Location:162 → 349
    Galactosyl_T; Galactosyltransferase

  2. NM_198540.2 → NP_940942.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

    See identical proteins and their annotated locations for NP_940942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AY277592
    Consensus CDS
    CCDS12582.1
    UniProtKB/Swiss-Prot
    Q7Z7M8
    Related
    ENSP00000312700.1, ENST00000321702.2
    Conserved Domains (1) summary
    cl21608
    Location:162 → 349
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41425359..41428730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44246583..44249963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7M8.1 GenPept UniProtKB/Swiss-Prot:Q7Z7M8

Gene LinkOut

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