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TMEM205 transmembrane protein 205 [ Homo sapiens (human) ]

Gene ID: 374882, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM205provided by HGNC
Official Full Name
transmembrane protein 205provided by HGNC
Primary source
HGNC:HGNC:29631
See related
Ensembl:ENSG00000105518 MIM:613771; AllianceGenome:HGNC:29631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ501
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 32.8), thyroid (RPKM 28.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11342778..11346492, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11469756..11473392, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11453454..11456944, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetraspanin 16 Neighboring gene uncharacterized HSPC102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14008 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11456465-11457295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11461146-11461646 Neighboring gene coiled-coil domain containing 159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11467020-11467961 Neighboring gene phospholipid phosphatase related 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeting TMEM205 mediated drug resistance in ovarian clear cell carcinoma using oncolytic virus. Saini U, et al. J Ovarian Res, 2022 Dec 7. PMID 36476493, Free PMC Article
  2. A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion. Gallenito MJ, et al. Metallomics, 2020 Oct 21. PMID 32789331, Free PMC Article
  3. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. Shen DW, et al. J Cell Physiol, 2010 Nov. PMID 20589834, Free PMC Article
  4. The association of transporter genes polymorphisms and lung cancer chemotherapy response. Wang Y, et al. PLoS One, 2014. PMID 24643204, Free PMC Article
  5. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107411

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion.
    Title: A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion.
  2. The genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205 may contribute to chemotherapy response in lung cancer patients.
    Title: The association of transporter genes polymorphisms and lung cancer chemotherapy response.
  3. Results indicate that a novel mechanism for cisplatin resistance is mediated by TMEM205 overexpression.
    Title: Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3205, MGC110858

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 205
Names
MBC3205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145416.2 → NP_001138888.1  transmembrane protein 205

    See identical proteins and their annotated locations for NP_001138888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC091472, BE889078
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000468733.1, ENST00000593256.6
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

  2. NM_001321112.2 → NP_001308041.1  transmembrane protein 205

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC024575, BQ639667, CB994930
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000466495.1, ENST00000588560.5
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

  3. NM_001321113.2 → NP_001308042.1  transmembrane protein 205

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC024575, BM352837, CB994930
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000466986.1, ENST00000586590.5
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

  4. NM_001321114.2 → NP_001308043.1  transmembrane protein 205

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    BM451378, CB994930
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000465553.1, ENST00000589555.5
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

  5. NM_033408.4 → NP_212133.1  transmembrane protein 205

    See identical proteins and their annotated locations for NP_212133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC008365, BE889078
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000398258.1, ENST00000447337.5
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

  6. NM_198536.3 → NP_940938.1  transmembrane protein 205

    See identical proteins and their annotated locations for NP_940938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    BC064948, BC091472, BE889078
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000346954.4, ENST00000354882.10
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11342778..11346492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451501.2 → XP_024307269.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000465149.1, ENST00000587948.5
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

  2. XM_024451500.2 → XP_024307268.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

  3. XM_005259899.3 → XP_005259956.1  transmembrane protein 205 isoform X1

    See identical proteins and their annotated locations for XP_005259956.1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000465483.1, ENST00000586956.5
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 114
    DUF4149; Domain of unknown function (DUF4149)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11469756..11473392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320915.1 → XP_054176890.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68

  2. XM_054320914.1 → XP_054176889.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UW68.1 GenPept UniProtKB/Swiss-Prot:Q6UW68

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