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NC2alpha Negative Cofactor 2alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37471, updated on 11-Sep-2024

Summary

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Official Symbol
NC2alphaprovided by FlyBase
Official Full Name
Negative Cofactor 2alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0034650
Locus tag
Dmel_CG10318
See related
AllianceGenome:FB:FBgn0034650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10318; dDrap; dDrap1; dDrap1/dNC2a; Dmel\CG10318; dNC2; Dr1-Drap1; Drap1; NC2; Nc2alpha
Summary
Enables core promoter sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in organism and pole plasm. Orthologous to human DRAP1 (DR1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See NC2alpha in Genome Data Viewer
Location:
57F7-57F7; 2-96 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21670152..21671593)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17557657..17559098)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene uncharacterized protein Neighboring gene stumble

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxymoron no more: the expanding world of heterochromatic genes. Yasuhara JC, et al. Trends Genet, 2006 Jun. PMID 16690158
  2. A basal transcription factor that activates or represses transcription. Willy PJ, et al. Science, 2000 Nov 3. PMID 11062130
  3. The RNA Polymerase II Core Promoter in Drosophila. Vo Ngoc L, et al. Genetics, 2019 May. PMID 31053615, Free PMC Article
  4. TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription. Hsu JY, et al. Genes Dev, 2008 Sep 1. PMID 18703680, Free PMC Article
  5. Maternal RNAs encoding transcription factors for germline-specific gene expression in Drosophila embryos. Yatsu J, et al. Int J Dev Biol, 2008. PMID 18956321

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of negative cofactor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
negative cofactor 2alpha
Names
CG10318-PA
NC2alpha-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21670152..21671593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137757.3 → NP_611601.2  negative cofactor 2alpha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611601.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GSP1, Q9W2E3
    Related
    FBpp0071583
    Conserved Domains (1) summary
    pfam00808
    Location:11 → 74
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MLV5 Q8MLV5
Q9GSP1 Q9GSP1
Q9W2E3 Q9W2E3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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