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Egfr Epidermal growth factor receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37455, updated on 14-Nov-2024

Summary

Official Symbol
Egfrprovided by FlyBase
Official Full Name
Epidermal growth factor receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0003731
Locus tag
Dmel_CG10079
See related
AllianceGenome:FB:FBgn0003731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; degfr; dEgfr; dEGFr; dEGFR; Degfr; DEgfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; Dmel\CG10079; DmHD-33; EC2-4; EFG-R; Egf; EGF; Egf-r; EGF-R; egfr; EgfR; EgFr; EGfr; EGFr; EGFR; EK2-6; El; Elp; Elp-1; Elp-B1; Elp-B1RB1; flb; HD-33; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57Ea; l(2)57EFa; mor1; top; Top; TOP; top/DER; top/flb; Torpedo; Torpedo/DER; torpedo/egfr; torpedo/Egfr; Torpedo/Egfr
Summary
Enables epidermal growth factor receptor activity. Involved in several processes, including compound eye morphogenesis; open tracheal system development; and regionalization. Located in plasma membrane. Is active in apical plasma membrane. Colocalizes with cytoneme. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; germ layer; gut section; and imaginal disc. Used to study alcohol use disorder; carcinoma; cardiomyopathy; and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Egfr in Genome Data Viewer
Location:
57E9-57F1; 2-95 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21522420..21559977)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17409925..17447482)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44725 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tiwaz Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables epidermal growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in R8 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in border follicle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell projection assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in chorion-containing eggshell pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in compound eye cone cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of genital disc primordium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure, spreading of leading edge cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye-antennal disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-band shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-line stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in haltere development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leg disc proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lumen formation, open tracheal system IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of epithelial integrity, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in morphogenesis of follicular epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of compound eye retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in notum cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in notum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oenocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ommatidial rotation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in photoreceptor cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of border follicle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in second mitotic wave involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in segment polarity determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spiracle morphogenesis, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tracheal outgrowth, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wing and notum subfield formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wing disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with cytoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
epidermal growth factor receptor
Names
CG10079-PA
CG10079-PB
DER-Ellipse
EGF-receptor
EGFR
Egf receptor
Egfr-PA
Egfr-PB
dEGFR
drosophila epidermal growth factor receptor
drosophila epidermal growth factor receptor homologue
ellipse
ellipse torpedo
faint little ball
morphological defects 1
torpedo
torpedo/DER
NP_476758.1
NP_476759.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21522420..21559977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057410.4 → NP_476758.1  epidermal growth factor receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476758.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6SAN1, Q8MLW0
    Related
    FBpp0071570
    Conserved Domains (7) summary
    smart00221
    Location:889 → 1145
    STYKc; Protein kinase; unclassified specificity
    smart00261
    Location:568 → 610
    FU; Furin-like repeats
    cd00064
    Location:253 → 296
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05057
    Location:881 → 1159
    PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases
    pfam00757
    Location:204 → 352
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:370 → 498
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:523 → 635
    GF_recep_IV; Growth factor receptor domain IV
  2. NM_057411.4 → NP_476759.1  epidermal growth factor receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476759.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18370, O61601, P04412, P81868, Q9W2G0
    Related
    FBpp0071571
    Conserved Domains (7) summary
    smart00221
    Location:938 → 1194
    STYKc; Protein kinase; unclassified specificity
    smart00261
    Location:617 → 659
    FU; Furin-like repeats
    cd00064
    Location:302 → 345
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05057
    Location:930 → 1208
    PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases
    pfam00757
    Location:253 → 401
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:419 → 547
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:572 → 684
    GF_recep_IV; Growth factor receptor domain IV