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TP63 tumor protein p63 [ Gallus gallus (chicken) ]

Gene ID: 374269, updated on 6-Jun-2024

Summary

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Symbol
TP63provided by CGNC
Full Name
tumor protein p63provided by CGNC
Primary source
CGNC:49111
See related
Ensembl:ENSGALG00010014867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TP73L; TRP63; deltaNp63; TAp63alpha
Orthologs
human mouse all
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Genomic context

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See TP63 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (13741157..13844545, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (13536717..13639950, complement)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene claudin 1 Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene uncharacterized LOC121111464 Neighboring gene uncharacterized LOC101751159 Neighboring gene uncharacterized LOC107054098

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma. Pokorna Z, et al. Cell Mol Biol Lett, 2022 Feb 23. PMID 35196980, Free PMC Article
  2. TP63 Transcripts Play Opposite Roles in Chicken Skeletal Muscle Differentiation. Luo W, et al. Front Physiol, 2018. PMID 30283353, Free PMC Article
  3. The expression of p63 and Ck HMW in magnum and infundibulum of Gallus domesticus oviduct. Stadnicka K, et al. Folia Biol (Krakow), 2014. PMID 25403071
  4. Cloning and expression of the chick p63 gene. Yasue A, et al. Mech Dev, 2001 Jan. PMID 11118893
  5. Cell senescence, apoptosis and DNA damage cooperate in the remodeling processes accounting for heart morphogenesis. Lorda-Diez CI, et al. J Anat, 2019 Jun. PMID 30875434, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identifying pathways regulating the oncogenic p53 family member DeltaNp63 provides therapeutic avenues for squamous cell carcinoma.
    Title: Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma.
  2. Our analysis identified p63 as the most expressed member of the p53 gene family in areas of programmed cell death and senescence associated with the remodeling of the outflow tract to construct the roots of the great arteries and with septation of the cardiac cavities during the development of the heart in the chicken embryo.
    Title: Cell senescence, apoptosis and DNA damage cooperate in the remodeling processes accounting for heart morphogenesis.
  3. The expression of p63 in nuclei of luminal cells was significantly higher in the infundibulum, compared to the magnum section.
    Title: The expression of p63 and Ck HMW in magnum and infundibulum of Gallus domesticus oviduct.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor protein 63
Names
DeltaNp63alpha
transformation related protein 63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398391.1 → NP_001385320.1  tumor protein 63 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A3Q3A2R8, A0A8V0YWX3
    Related
    ENSGALP00010020806.1, ENSGALT00010035868.1
    Conserved Domains (2) summary
    cd08367
    Location:138 → 319
    P53; P53 DNA-binding domain
    cd09572
    Location:504 → 568
    SAM_tumor-p63; SAM domain of tumor-p63 proteins

  2. NM_001398392.1 → NP_001385321.1  tumor protein 63 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A3Q2TZ71, A0A8V0YWX3
    Related
    ENSGALP00010020793.1, ENSGALT00010035854.1
    Conserved Domains (2) summary
    cd08367
    Location:138 → 319
    P53; P53 DNA-binding domain
    cd09572
    Location:500 → 564
    SAM_tumor-p63; SAM domain of tumor-p63 proteins

  3. NM_001398393.1 → NP_001385322.1  tumor protein 63 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A167VDT2, A0A8V0YWX3
    Related
    ENSGALP00010020797.1, ENSGALT00010035859.1
    Conserved Domains (3) summary
    cd08367
    Location:177 → 358
    P53; P53 DNA-binding domain
    cd09572
    Location:543 → 607
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    pfam07710
    Location:392 → 428
    P53_tetramer; P53 tetramerisation motif

  4. NM_001398394.1 → NP_001385323.1  tumor protein 63 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A8V0YIP3
    Conserved Domains (2) summary
    cd08367
    Location:77 → 258
    P53; P53 DNA-binding domain
    cd09572
    Location:439 → 503
    SAM_tumor-p63; SAM domain of tumor-p63 proteins

  5. NM_001398395.1 → NP_001385324.1  tumor protein 63 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A8V0YIP3
    Related
    ENSGALP00010020780.1, ENSGALT00010035834.1
    Conserved Domains (3) summary
    cd08367
    Location:77 → 258
    P53; P53 DNA-binding domain
    cd09572
    Location:443 → 507
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    pfam07710
    Location:292 → 328
    P53_tetramer; P53 tetramerisation motif

  6. NM_001398396.1 → NP_001385325.1  tumor protein 63 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A167VDV3, F1NWD0, Q9DEC7
    Related
    ENSGALP00010020790.1, ENSGALT00010035848.1
    Conserved Domains (3) summary
    cd08367
    Location:83 → 264
    P53; P53 DNA-binding domain
    cd09572
    Location:449 → 513
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    pfam07710
    Location:298 → 334
    P53_tetramer; P53 tetramerisation motif

  7. NM_001398397.1 → NP_001385326.1  tumor protein 63 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    Conserved Domains (1) summary
    cd08367
    Location:83 → 264
    P53; P53 DNA-binding domain

  8. NM_204351.2 → NP_989682.2  tumor protein 63 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    Q9DEC7

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    13741157..13844545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046898296.1 → XP_046754252.1  tumor protein 63 isoform X1

    UniProtKB/TrEMBL
    A0A167VDT2, A0A8V0YWX3

  2. XM_046898297.1 → XP_046754253.1  tumor protein 63 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3A2R8, A0A8V0YWX3

  3. XM_046898299.1 → XP_046754255.1  tumor protein 63 isoform X4

  4. XM_046898298.1 → XP_046754254.1  tumor protein 63 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YIP3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    13536717..13639950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046923533.1 → XP_046779489.1  tumor protein 63 isoform X1

    UniProtKB/TrEMBL
    A0A167VDT2, A0A8V0YWX3

  2. XM_046923535.1 → XP_046779491.1  tumor protein 63 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2TZ71, A0A8V0YWX3

  3. XM_046923534.1 → XP_046779490.1  tumor protein 63 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3A2R8, A0A8V0YWX3

  4. XM_046923537.1 → XP_046779493.1  tumor protein 63 isoform X4

  5. XM_046923536.1 → XP_046779492.1  tumor protein 63 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YIP3
Nucleotide Protein Strain
Heading Accession and Version

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