U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ugt49C1 UDP-glycosyltransferase family 49 member C1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37421, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ugt49C1provided by FlyBase
Official Full Name
UDP-glycosyltransferase family 49 member C1provided by FlyBase
Primary source
FLYBASE:FBgn0034605
Locus tag
Dmel_CG15661
See related
AllianceGenome:FB:FBgn0034605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15661; Dmel\CG15661; UGT49C1
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to several human genes including UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ugt49C1 in Genome Data Viewer
Location:
57D2-57D2; 2-94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21215435..21217779, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17102940..17105284, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycogenin Neighboring gene UDP-glycosyltransferase family 49 member B1 Neighboring gene Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein Neighboring gene Rad, Gem/Kir family member 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lamin Dysfunction Mediates Neurodegeneration in Tauopathies. Frost B, et al. Curr Biol, 2016 Jan 11. PMID 26725200, Free PMC Article
  2. Tau promotes neurodegeneration through global chromatin relaxation. Frost B, et al. Nat Neurosci, 2014 Mar. PMID 24464041, Free PMC Article
  3. The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis. Ahn SJ, et al. Front Physiol, 2021. PMID 33815151, Free PMC Article
  4. Functional and phylogenetic analyses of a putative Drosophila melanogaster UDP-glycosyltransferase gene. Luque T, et al. Insect Biochem Mol Biol, 2002 Dec. PMID 12429111
  5. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glycosyltransferase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycosylation ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
UDP-glycosyltransferase family 49 member C1
Names
CG15661-PA
CG15661-PB
Ugt49C1-PA
Ugt49C1-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21215435..21217779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137720.4 → NP_611564.2  UDP-glycosyltransferase family 49 member C1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611564.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V5F2, Q4V5J6, Q4V5L6, Q9W2J3
    Conserved Domains (2) summary
    PHA03392
    Location:22 → 504
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:37 → 498
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

  2. NM_001043100.3 → NP_001036565.1  UDP-glycosyltransferase family 49 member C1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V5F2, Q4V5J6, Q4V5L6, Q9W2J3
    Conserved Domains (2) summary
    PHA03392
    Location:22 → 504
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:37 → 498
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2J3 Q9W2J3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous