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Gyg Glycogenin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37419, updated on 11-Sep-2024

Summary

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Official Symbol
Gygprovided by FlyBase
Official Full Name
Glycogeninprovided by FlyBase
Primary source
FLYBASE:FBgn0265191
Locus tag
Dmel_CG44244
See related
AllianceGenome:FB:FBgn0265191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG44244; CG9480; Dmel\CG44244; NEST:bs16a02
Old locus tag
Dmel_CG9480
Summary
Predicted to enable glycogenin glucosyltransferase activity. Predicted to be involved in glycogen biosynthetic process. Located in cytosol. Is expressed in several structures, including adult heart; embryonic/larval muscle system; extended germ band embryo; spermatozoon; and visceral muscle primordium. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to several human genes including GYG1 (glycogenin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
57D1-57D1; 2-94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21200483..21210821)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17087988..17098326)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tudor Neighboring gene Leucine-rich repeat activity-regulated protein at synapses Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 49 member B1 Neighboring gene UDP-glycosyltransferase family 49 member C1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila embryos spatially sort their nutrient stores to facilitate their utilization. Kilwein MD, et al. Development, 2023 Oct 15. PMID 36805634, Free PMC Article
  2. Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster. Zhang HB, et al. PLoS Pathog, 2021 Aug. PMID 34383852, Free PMC Article
  3. Disrupted Glutamate Signaling in Drosophila Generates Locomotor Rhythms in Constant Light. de Azevedo RVM, et al. Front Physiol, 2020. PMID 32210832, Free PMC Article
  4. Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding. Silicheva M, et al. Nucleic Acids Res, 2010 Jan. PMID 19854952, Free PMC Article
  5. Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Liu LP, et al. Nat Genet, 2005 Dec. PMID 16258543

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycogenin glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
glycogenin
Names
CG44244-PB
CG44244-PD
CG44244-PE
CG44244-PG
CG44244-PH
CG44244-PI
Gyg-PB
Gyg-PD
Gyg-PE
Gyg-PG
Gyg-PH
Gyg-PI
NP_001163232.2
NP_001246446.1
NP_001286666.1
NP_001286667.1
NP_001286668.1
NP_726040.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21200483..21210821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299737.1 → NP_001286666.1  glycogenin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFW5
    Conserved Domains (2) summary
    cd02537
    Location:4 → 253
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:94 → 251
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

  2. NM_001299739.1 → NP_001286668.1  glycogenin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG72
    Conserved Domains (2) summary
    cd02537
    Location:4 → 253
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:94 → 251
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

  3. NM_001299738.1 → NP_001286667.1  glycogenin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG29
    Conserved Domains (2) summary
    cd02537
    Location:4 → 253
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:94 → 251
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

  4. NM_001259517.2 → NP_001246446.1  glycogenin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246446.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7X5
    Conserved Domains (2) summary
    cd02537
    Location:4 → 253
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:94 → 251
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

  5. NM_166432.3 → NP_726040.1  glycogenin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726040.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2J6
    Related
    FBpp0308233
    Conserved Domains (2) summary
    cd02537
    Location:4 → 253
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:94 → 251
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

  6. NM_001169761.4 → NP_001163232.2  glycogenin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163232.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGQ3
    Conserved Domains (2) summary
    cd02537
    Location:1 → 207
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:48 → 205
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7X5 A0A0B4K7X5
A0A0B4LFW5 A0A0B4LFW5
A0A0B4LG29 A0A0B4LG29
A0A0B4LG72 A0A0B4LG72
E1JGQ3 E1JGQ3
Q9W2J6 Q9W2J6

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