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CACNA1B calcium voltage-gated channel subunit alpha1 B [ Gallus gallus (chicken) ]

Gene ID: 374169, updated on 17-Aug-2024

Summary

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Symbol
CACNA1Bprovided by CGNC
Full Name
calcium voltage-gated channel subunit alpha1 Bprovided by CGNC
Primary source
CGNC:49068
See related
Ensembl:ENSGALG00010028762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Cav2.2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
52
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (2776250..3036456)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (2184826..2444837)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene arrestin domain containing 1 Neighboring gene euchromatic histone lysine methyltransferase 1 Neighboring gene microRNA 7441 Neighboring gene collagen type I alpha 4 chain Neighboring gene solute carrier family 31 member 2 Neighboring gene family with sequence similarity 129 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long C terminal splice variant CaV2.2 identified in presynaptic membrane by mass spectrometric analysis. Gardezi SR, et al. Channels (Austin), 2010 Jan-Feb. PMID 20368691
  2. Cloning and functional expression of novel N-type Ca(2+) channel variants. Lü Q, et al. J Biol Chem, 1999 Dec 3. PMID 10574919
  3. Localization of individual calcium channels at the release face of a presynaptic nerve terminal. Haydon PG, et al. Neuron, 1994 Dec. PMID 7993621
  4. RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel. Richman RW, et al. J Biol Chem, 2005 Jan 14. PMID 15536086
  5. Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein. Chan AW, et al. Channels (Austin), 2007 Jan-Feb. PMID 19170253

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RGS12 binds to the SNARE-binding or "synprint" region (amino acids 726-985) in loop II-III of the Cav2.2 calcium channel alpha1 subunit
    Title: RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel.
  2. Identify of the long-splice Ca(V)2.2 in synaptosomes prepared from chick embryo brain.
    Title: Long C terminal splice variant CaV2.2 identified in presynaptic membrane by mass spectrometric analysis.
  3. Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.
    Title: Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent N-type calcium channel subunit alpha-1B
Names
CHCACHA1B
N-type voltage-gated calcium channel alpha1B subunit ChCaChA1B
calcium channel, voltage-dependent, L type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit
voltage-gated calcium channel subunit alpha Cav2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204293.2 → NP_989624.2  voltage-dependent N-type calcium channel subunit alpha-1B

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000308
    UniProtKB/TrEMBL
    Q9PUM6
    Conserved Domains (3) summary
    smart01062
    Location:1869 → 1899
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:857 → 1033
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2119 → 2276
    Transformer; Fruit fly transformer protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2776250..3036456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015279262.4 → XP_015134748.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1894 → 1924
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:878 → 1054
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2132 → 2289
    Transformer; Fruit fly transformer protein

  2. XM_015279261.4 → XP_015134747.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1894 → 1924
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:878 → 1054
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2132 → 2289
    Transformer; Fruit fly transformer protein

  3. XM_015279263.4 → XP_015134749.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1892 → 1922
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:878 → 1054
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2130 → 2287
    Transformer; Fruit fly transformer protein

  4. XM_015279264.4 → XP_015134750.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1890 → 1920
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:878 → 1054
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2128 → 2285
    Transformer; Fruit fly transformer protein

  5. XM_015279266.4 → XP_015134752.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1888 → 1918
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:878 → 1054
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2126 → 2283
    Transformer; Fruit fly transformer protein

  6. XM_015279265.4 → XP_015134751.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1888 → 1918
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:878 → 1054
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2126 → 2283
    Transformer; Fruit fly transformer protein

  7. XM_025156019.3 → XP_025011787.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Related
    ENSGALP00010042870.1, ENSGALT00010069609.1
    Conserved Domains (3) summary
    smart01062
    Location:1871 → 1901
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:857 → 1033
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2109 → 2266
    Transformer; Fruit fly transformer protein

  8. XM_015279276.4 → XP_015134762.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

    UniProtKB/TrEMBL
    Q9PUM5
    Conserved Domains (2) summary
    smart01062
    Location:1869 → 1899
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:857 → 1033
    PRK12678; transcription termination factor Rho; Provisional

  9. XM_015279270.4 → XP_015134756.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1867 → 1897
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:857 → 1033
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2105 → 2262
    Transformer; Fruit fly transformer protein

  10. XM_015279267.4 → XP_015134753.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1883 → 1913
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:867 → 1043
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2121 → 2278
    Transformer; Fruit fly transformer protein

  11. XM_015279268.4 → XP_015134754.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

    UniProtKB/TrEMBL
    Q9PW47
    Conserved Domains (3) summary
    smart01062
    Location:1858 → 1888
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:846 → 1022
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2108 → 2265
    Transformer; Fruit fly transformer protein

  12. XM_015279277.4 → XP_015134763.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X19

    UniProtKB/TrEMBL
    Q9PW46
    Conserved Domains (2) summary
    smart01062
    Location:1858 → 1888
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:846 → 1022
    PRK12678; transcription termination factor Rho; Provisional

  13. XM_015279269.4 → XP_015134755.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1869 → 1899
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:853 → 1029
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2107 → 2264
    Transformer; Fruit fly transformer protein

  14. XM_015279273.4 → XP_015134759.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

    UniProtKB/TrEMBL
    A0A8V1AJW5
    Conserved Domains (3) summary
    smart01062
    Location:1846 → 1876
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:832 → 1008
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2084 → 2241
    Transformer; Fruit fly transformer protein

  15. XM_015279272.4 → XP_015134758.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

    UniProtKB/TrEMBL
    Q9PW45
    Conserved Domains (3) summary
    smart01062
    Location:1844 → 1874
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:832 → 1008
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2094 → 2251
    Transformer; Fruit fly transformer protein

  16. XM_015279278.4 → XP_015134764.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X20

    UniProtKB/TrEMBL
    Q9PW44
    Conserved Domains (2) summary
    smart01062
    Location:1844 → 1874
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:832 → 1008
    PRK12678; transcription termination factor Rho; Provisional

  17. XM_025156020.3 → XP_025011788.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

    UniProtKB/TrEMBL
    Q9PW45
    Conserved Domains (3) summary
    smart01062
    Location:1842 → 1872
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:832 → 1008
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2080 → 2237
    Transformer; Fruit fly transformer protein

  18. XM_015279271.4 → XP_015134757.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

    UniProtKB/TrEMBL
    Q9PUM4
    Conserved Domains (3) summary
    smart01062
    Location:1858 → 1888
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:842 → 1018
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2096 → 2253
    Transformer; Fruit fly transformer protein

  19. XM_015279274.4 → XP_015134760.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

    UniProtKB/TrEMBL
    Q9PUM4
    Related
    ENSGALP00010042865.1, ENSGALT00010069604.1
    Conserved Domains (3) summary
    smart01062
    Location:1833 → 1863
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:821 → 997
    PRK12678; transcription termination factor Rho; Provisional
    pfam06495
    Location:2083 → 2240
    Transformer; Fruit fly transformer protein

  20. XM_015279279.4 → XP_015134765.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X21

    UniProtKB/TrEMBL
    Q9PUM3
    Conserved Domains (2) summary
    smart01062
    Location:1833 → 1863
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:821 → 997
    PRK12678; transcription termination factor Rho; Provisional

  21. XM_015279275.4 → XP_015134761.3  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

    UniProtKB/TrEMBL
    Q9PUM5
    Conserved Domains (2) summary
    smart01062
    Location:1894 → 1924
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    PRK12678
    Location:878 → 1054
    PRK12678; transcription termination factor Rho; Provisional

RNA

  1. XR_001464423.4 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2184826..2444837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928648.1 → XP_046784604.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

    UniProtKB/TrEMBL
    A0A8V1AJW5

  2. XM_046928646.1 → XP_046784602.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

    UniProtKB/TrEMBL
    A0A8V1AJW5

  3. XM_046928649.1 → XP_046784605.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

    UniProtKB/TrEMBL
    A0A8V1AJW5

  4. XM_046928650.1 → XP_046784606.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

    UniProtKB/TrEMBL
    A0A8V1AJW5

  5. XM_046928652.1 → XP_046784608.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

    UniProtKB/TrEMBL
    Q9PUM6

  6. XM_046928651.1 → XP_046784607.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

    UniProtKB/TrEMBL
    A0A8V1AJW5

  7. XM_046928654.1 → XP_046784610.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

    UniProtKB/TrEMBL
    A0A8V1AJW5

  8. XM_046928665.1 → XP_046784621.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

    UniProtKB/TrEMBL
    Q9PUM5

  9. XM_046928658.1 → XP_046784614.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

    UniProtKB/TrEMBL
    A0A8V1AJW5

  10. XM_046928653.1 → XP_046784609.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

    UniProtKB/TrEMBL
    A0A8V1AJW5

  11. XM_046928655.1 → XP_046784611.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

    UniProtKB/TrEMBL
    Q9PW47

  12. XM_046928666.1 → XP_046784622.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X19

    UniProtKB/TrEMBL
    Q9PW46

  13. XM_046928656.1 → XP_046784612.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

    UniProtKB/TrEMBL
    A0A8V1AJW5

  14. XM_046928661.1 → XP_046784617.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

    UniProtKB/TrEMBL
    A0A8V1AJW5

  15. XM_046928660.1 → XP_046784616.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

    UniProtKB/TrEMBL
    Q9PW45

  16. XM_046928667.1 → XP_046784623.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X20

    UniProtKB/TrEMBL
    Q9PW44

  17. XM_046928663.1 → XP_046784619.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

    UniProtKB/TrEMBL
    Q9PW45

  18. XM_046928659.1 → XP_046784615.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

    UniProtKB/TrEMBL
    Q9PUM4

  19. XM_046928662.1 → XP_046784618.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

    UniProtKB/TrEMBL
    Q9PUM4

  20. XM_046928668.1 → XP_046784624.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X21

    UniProtKB/TrEMBL
    Q9PUM3

  21. XM_046928664.1 → XP_046784620.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

    UniProtKB/TrEMBL
    Q9PUM5

RNA

  1. XR_006936398.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O73706.1 GenPept UniProtKB/Swiss-Prot:O73706

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