CCN2 cellular communication network factor 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CCN2provided by CGNC
Official Full Name: cellular communication network factor 2provided by CGNC
Primary source: CGNC:2102
See related: Ensembl:ENSGALG00010004251
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: NOV; CTGF
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (56836500..56839471)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (56744789..56747762)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adventitial growth and lung connective tissue growth factor expression in pulmonary arterioles due to hypobaric hypoxia in broilers.
Title: Adventitial growth and lung connective tissue growth factor expression in pulmonary arterioles due to hypobaric hypoxia in broilers.
application of exogenous CCN2 protein caused ERK1/2 activation, and the neutralizing CCN2 antibody inhibited loading-induced ERK1/2 activation.
Title: Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway.
Ccn2 was expressed in the prehypertrophic cartilage of the digit rays and, with a lower intensity, in the developing joints. Interdigital implantation of beads bearing CCN2 exhibited the same effects as CCN1 but caused an additional moderate upregulation of Sox9, Activin beta-A and alpha 5 Integrin.
Title: Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.
Differential occupancy of the TCF x LEF x Sox9 site by Sox9 versus beta-catenin restricts high levels of Ccn2 expression to hypertrophic chondrocytes.
Title: Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.
CTGF genes and proteins are expressed at high or moderately high levels in healing tendon
Title: Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period.
The present study reveals a novel aspect of NPM/B23 as a key player in the posttranscriptional regulation of ccn2 mRNA during the differentiation of chondrocytes.
Title: Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.
gene expression of CTGF mRNA during endochondral ossification is properly regulated, at least in part, by changing the stability of the mRNA, which arises from the interaction between the RNA cis-element and putative trans-factor.
Title: Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative trans-factor during differentiation of chondrocytes.
Retinoids appear to have a preeminent role in controlling expression and function of CTGF in hypertrophic and posthypertrophic chondrocytes with differential cooperation and intervention of MAP kinases and BMP signaling
Title: Retinoid signaling regulates CTGF expression in hypertrophic chondrocytes with differential involvement of MAP kinases.
Differences in the expression of 5 proteins in the lungs of chickens with or without pulmonary hypertension are reported.
Title: Endothelin 1, its endothelin type A receptor, connective tissue growth factor, platelet-derived growth factor, and adrenomedullin expression in lungs of pulmonary hypertensive and nonhypertensive chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CCN family member 2

Names: connective tissue growth factor; nephroblastoma overexpressed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204274.2 → NP_989605.1 CCN family member 2 precursor

See identical proteins and their annotated locations for NP_989605.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000063

UniProtKB/TrEMBL

F1NBR5, Q98TQ8

Related

ENSGALP00010005838.1, ENSGALT00010009955.1

Conserved Domains (4) summary

smart00209
Location:197 → 238

TSP1; Thrombospondin type 1 repeats

smart00214
Location:98 → 157

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:24 → 77

IGFBP; Insulin-like growth factor binding protein

cl21545
Location:248 → 340

GHB_like; Glycoprotein hormone beta chain homologues