NR3C2 nuclear receptor subfamily 3 group C member 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: NR3C2provided by CGNC
Full Name: nuclear receptor subfamily 3 group C member 2provided by CGNC
Primary source: CGNC:49053
See related: Ensembl:ENSGALG00010006735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MR
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (31695484..31897457, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (31648287..31850096, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progesterone: An enigmatic ligand for the mineralocorticoid receptor.
Title: Progesterone: An enigmatic ligand for the mineralocorticoid receptor.
cortisone and aldosterone induced cGR- and cMR-driven transcriptional activity in a dose-dependent manner; Each receptor responded to both steroids, but cMR transcriptional activity was induced by lower levels of CORT and ALDO than cGR
Title: Functional characterization of chicken glucocorticoid and mineralocorticoid receptors.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mineralocorticoid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159345.2 → NP_001152817.2 mineralocorticoid receptor

Status: VALIDATED

Source sequence(s)

JAENSK010000073

UniProtKB/TrEMBL

A0A8V0XTC3

Related

ENSGALP00010009237.1, ENSGALT00010016071.1

Conserved Domains (3) summary

cd07075
Location:734 → 981

NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:602 → 674

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam05109
Location:187 → 382

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
NM_001397849.1 → NP_001384778.1 mineralocorticoid receptor

Status: VALIDATED

Source sequence(s)

JAENSK010000073

UniProtKB/TrEMBL

A0A8V0XTC3

Related

ENSGALP00010009238.1, ENSGALT00010016075.1

Conserved Domains (3) summary

cd07075
Location:734 → 981

NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:602 → 674

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam05109
Location:187 → 382

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

31695484..31897457 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046939845.1 → XP_046795801.1 mineralocorticoid receptor isoform X1

UniProtKB/TrEMBL

A0A8V0XM19

Related

ENSGALP00010009239.1, ENSGALT00010016080.1
XM_015276102.4 → XP_015131588.2 mineralocorticoid receptor isoform X2

UniProtKB/TrEMBL

A0A8V0XTC3, A0A8V0XW48

Related

ENSGALP00010009236.1, ENSGALT00010016070.1

Conserved Domains (3) summary

cd07075
Location:734 → 981

NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:602 → 674

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam05109
Location:187 → 382

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_046939847.1 → XP_046795803.1 mineralocorticoid receptor isoform X3
XM_040698667.2 → XP_040554601.1 mineralocorticoid receptor isoform X4

Conserved Domains (2) summary

cd07075
Location:153 → 400

NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:21 → 93

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
XM_025149460.3 → XP_025005228.1 mineralocorticoid receptor isoform X3

Conserved Domains (2) summary

cd07075
Location:196 → 443

NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:64 → 136

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
XM_046939848.1 → XP_046795804.1 mineralocorticoid receptor isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

31648287..31850096 complement

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GenBank, FASTA, Sequence Viewer (Graphics)