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mago mago nashi [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37402, updated on 18-Sep-2024

Summary

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Official Symbol
magoprovided by FlyBase
Official Full Name
mago nashiprovided by FlyBase
Primary source
FLYBASE:FBgn0002736
Locus tag
Dmel_CG9401
See related
AllianceGenome:FB:FBgn0002736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9401; Dm MGN; Dmel\CG9401; DmMago; l(2)57Ca; Mago; MAGO; Magoh; MAGOH; mgn; MGN
Summary
Involved in several processes, including negative regulation of transposition, DNA-mediated; oocyte microtubule cytoskeleton polarization; and regulation of pole plasm oskar mRNA localization. Located in nucleus and pole plasm. Part of exon-exon junction complex. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval nervous system; extended germ band embryo; germ layer; and gonad. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit) and MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See mago in Genome Data Viewer
Location:
57C2-57C2; 2-93 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21128577..21129737)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17016082..17017242)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene king tubby Neighboring gene uncharacterized protein Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 3 Neighboring gene magi Neighboring gene uncharacterized protein Neighboring gene X box binding protein-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos. Boswell RE, et al. Development, 1991 Sep. PMID 1765008
  2. Crystal structure of the Drosophila Mago nashi-Y14 complex. Shi H, et al. Genes Dev, 2003 Apr 15. PMID 12704080, Free PMC Article
  3. Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Hachet O, et al. Nature, 2004 Apr 29. PMID 15118729
  4. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. Bono F, et al. EMBO Rep, 2004 Mar. PMID 14968132, Free PMC Article
  5. A novel mode of RBD-protein recognition in the Y14-Mago complex. Fribourg S, et al. Nat Struct Biol, 2003 Jun. PMID 12730685

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAPK is the primary functional target of mago in eye development; in cultured cells, Mago knockdown disproportionately affects other large genes located in heterochromatin
    Title: Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene.
  2. Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster
    Title: Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster.
  3. mago nashi is required for germline stem cell differentiation, but surprisingly mago nashi functions independently of tsunagi/Y14 in this process
    Title: Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specification.
  4. We have determined the crystal structure of the complex between Drosophila melanogaster Y14 and Mago at a resolution of 2.5 A. The structure reveals an atypical mode of protein-protein recognition mediated by an RNA-binding domain (RBD).
    Title: A novel mode of RBD-protein recognition in the Y14-Mago complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in maintenance of pole plasm mRNA location TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton polarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in pole plasm oskar mRNA localization TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex IEA
Inferred from Electronic Annotation
more info
  
part_of exon-exon junction complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pole plasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
mago nashi
Names
CG9401-PA
mago nishi
mago-PA
mago-nashi

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21128577..21129737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057288.4 → NP_476636.1  mago nashi [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476636.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49028, Q9W2L3
    UniProtKB/TrEMBL
    A0A023T5E7
    Related
    FBpp0071497
    Conserved Domains (1) summary
    cd11295
    Location:5 → 147
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49028.1 P49028

Gene LinkOut

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