FABP1 fatty acid binding protein 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: FABP1provided by CGNC
Official Full Name: fatty acid binding protein 1provided by CGNC
Primary source: CGNC:11895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: LFABP; L-FABP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (85612157..85615889, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (85415911..85419643, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

L-FABP may affect lipid metabolism by regulating PPARalpha and L-BABP in chicken hepatocytes.
Title: Role of a liver fatty acid-binding protein gene in lipid metabolism in chicken hepatocytes.
Chickens under cold stress generate anti-oxidative stress and trigger the Nrf2/ARE signaling pathway, which further up-regulates L-FABP expression to inactivate cell membrane lipid peroxidation and promote fatty acid storage against the cold environment.
Title: Cold stress initiates the Nrf2/UGT1A1/L-FABP signaling pathway in chickens.
A high expression level of L-FABP and L-BABP leads to a high lipogenesis rate and, ultimately, to lipid deposition.
Title: Differential expression of L-FABP and L-BABP between fat and lean chickens.
The L-FABP gene was over-expressed in the liver tissue and contributed to the increased lipid deposition.
Title: [Whole cDNA sequence cloning and expression of chicken L-FABP gene and its relationship with lipid deposition of hybrid chickens].
investigation of the gene expression levels of L-FABP and Lb-FABP in relation to the pre-and post-hatching development, diurnal cycle and feeding state in the liver
Title: Characterization of critical factors influencing gene expression of two types of fatty acid-binding proteins (L-FABP and Lb-FABP) in the liver of birds.
The crystal structure of chicken liver basic type FABP complexed with cholic acid reveals that the FABP holoprotein and apoprotein crystallize in different space groups, and significant changes are observed between the two conformations.
Title: Crystal structure of chicken liver basic fatty acid-binding protein complexed with cholic acid.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fatty acid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fatty acid-binding protein, liver

Names: fatty acid binding protein 1, liver; fatty acid-binding protein; liver fatty acid binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204192.4 → NP_989523.1 fatty acid-binding protein, liver

See identical proteins and their annotated locations for NP_989523.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000077

UniProtKB/TrEMBL

Q90WA9

Conserved Domains (1) summary

cd19444
Location:2 → 127

FABP1; fatty acid-binding protein 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

85612157..85615889 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

85415911..85419643 complement

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GenBank, FASTA, Sequence Viewer (Graphics)