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Tmtc3 Transmembrane O-mannosyltransferase targeting cadherins 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37401, updated on 2-Nov-2024

Summary

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Official Symbol
Tmtc3provided by FlyBase
Official Full Name
Transmembrane O-mannosyltransferase targeting cadherins 3provided by FlyBase
Primary source
FLYBASE:FBgn0020312
Locus tag
Dmel_CG4050
See related
AllianceGenome:FB:FBgn0020312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-DM192; anon-j; CG4050; Dmel\CG4050; TMTC3
Summary
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central brain primordium; embryonic head sensory system; ganglia; larval nervous system; and ventral nerve cord primordium. Used to study epilepsy. Human ortholog(s) of this gene implicated in lissencephaly 8. Orthologous to human TMTC3 (transmembrane O-mannosyltransferase targeting cadherins 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Tmtc3 in Genome Data Viewer
Location:
57C2-57C2; 2-93 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21123735..21128510, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17011240..17016015, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein Neighboring gene king tubby Neighboring gene uncharacterized protein Neighboring gene mago nashi Neighboring gene magi Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy. Farhan SMK, et al. Hum Mol Genet, 2017 Nov 1. PMID 28973161, Free PMC Article
  2. Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. Eisenhaber B, et al. Biol Direct, 2021 Jan 12. PMID 33436046, Free PMC Article
  3. Recent Developments in Using Drosophila as a Model for Human Genetic Disease. Oriel C, et al. Int J Mol Sci, 2018 Jul 13. PMID 30011838, Free PMC Article
  4. Protein O-mannosylation: one sugar, several pathways, many functions. Koff M, et al. Glycobiology, 2023 Dec 25. PMID 37565810, Free PMC Article
  5. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane O-mannosyltransferase targeting cadherins 3
Names
CG4050-PA
CG4050-PB
Tmtc3-PA
Tmtc3-PB
transmembrane and tetratricopeptide repeat containing 3
NP_477246.2
NP_726030.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21123735..21128510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057898.4 → NP_477246.2  transmembrane O-mannosyltransferase targeting cadherins 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477246.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02435, Q24581, Q7K4B6
    UniProtKB/TrEMBL
    E2QCJ5
    Related
    FBpp0071560
    Conserved Domains (3) summary
    TIGR02917
    Location:513 → 871
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:598 → 625
    TPR; TPR repeat [structural motif]
    pfam08409
    Location:323 → 396
    DUF1736; Domain of unknown function (DUF1736)

  2. NM_166426.2 → NP_726030.1  transmembrane O-mannosyltransferase targeting cadherins 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726030.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02435, Q24581, Q7K4B6
    UniProtKB/TrEMBL
    E2QCJ5
    Related
    FBpp0071561
    Conserved Domains (3) summary
    TIGR02917
    Location:513 → 871
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:598 → 625
    TPR; TPR repeat [structural motif]
    pfam08409
    Location:323 → 396
    DUF1736; Domain of unknown function (DUF1736)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QCJ5 E2QCJ5
Q7K4B6.1 Q7K4B6

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