TYR tyrosinase [Gallus gallus (chicken)] - Gene

Summary

Symbol: TYRprovided by CGNC
Full Name: tyrosinaseprovided by CGNC
Primary source: CGNC:12952
See related: Ensembl:ENSGALG00010007864
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (187752871..187810203, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (187790729..187840571, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Among the 11 chicken tissues examined, the feather bulb, comb and skin showed higher levels of all TYR variants. All TYR variants were expressed at significantly different levels in black and white feather bulbs and may be involved in melanin formation in plumage.
Title: Five alternative splicing variants of the TYR gene and their different roles in melanogenesis in the Muchuan black-boned chicken.
Individuals with genotypes AA and AT had greater TYR expression than those with genotype TT. A luciferase assay of the promoter activity revealed that genotype AA had greater activity than genotype TT.
Title: A functional single nucleotide polymorphism in the tyrosinase gene promoter affects skin color and transcription activity in the black-boned chicken.
The co-segregation of plumage coloration and sequence polymorphism in TYR and MC1R genes were investigated using an intercross between black and white plumage color types of the Dongxiang blue-shelled chicken.
Title: Developmental phenotypic-genotypic associations of tyrosinase and melanocortin 1 receptor genes with changing profiles in chicken plumage pigmentation.
This study provided original information for elucidating the possible roles of exon-1 of TYR gene and 5' flanking region in chickens with different flesh color chicken.
Title: Flesh color association with polymorphism of the tyrosinase gene in different Chinese chicken breeds.
An avian retroviral sequence insertion in the tyrosinase gene was the cause of recessive white phenotype in chickens.
Title: Mapping of the recessive white locus and analysis of the tyrosinase gene in chickens.
Mutated proteins showed the insertion of a complete avian retroviral sequence of the Avian Leukosis Virus (ALV) family.
Title: Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tyrosinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in melanin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pigmentation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosinase

Names: monophenol monooxygenase; tyrosinase TYR-AS1; tyrosinase TYR-AS2; tyrosinase TYR-AS3; tyrosinase TYR-AS4; tyrosinase TYR-AS5

NP_989491.1

EC 1.14.18.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204160.2 → NP_989491.1 tyrosinase precursor

See identical proteins and their annotated locations for NP_989491.1

Status: VALIDATED

Source sequence(s)

JAENSK010000027

UniProtKB/Swiss-Prot

P55024

UniProtKB/TrEMBL

A0A411DFI8, Q91436

Related

ENSGALP00010010269.1, ENSGALT00010018719.1

Conserved Domains (2) summary

pfam00264
Location:171 → 403

Tyrosinase; Common central domain of tyrosinase

cl21504
Location:88 → 116

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

187752871..187810203 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

187790729..187840571 complement

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GenBank, FASTA, Sequence Viewer (Graphics)