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BCL2L1 BCL2 like 1 [ Gallus gallus (chicken) ]

Gene ID: 373954, updated on 17-Aug-2024

Summary

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Official Symbol
BCL2L1provided by CGNC
Official Full Name
BCL2 like 1provided by CGNC
Primary source
CGNC:4663
See related
Ensembl:ENSGALG00010014066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BCLX; BCL2L; bcl-x; Bcl-xl
Orthologs
human mouse all
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Genomic context

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See BCL2L1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (10357392..10375562, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (10139043..10157223, complement)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene bactericidal permeability-increasing protein-like Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene TPX2, microtubule nucleation factor Neighboring gene myosin light chain kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential expression of bcl-2 and bcl-x during chicken spermatogenesis. Vilagrasa X, et al. Mol Reprod Dev, 1997 May. PMID 9110311
  2. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Boise LH, et al. Cell, 1993 Aug 27. PMID 8358789
  3. The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers. Huang J, et al. Int J Environ Res Public Health, 2013 Dec 17. PMID 24351749, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mRNA expression was higher in Bax and Caspase-3, and lower in Bcl-2 of the 300, 600 and 900 mg/kg groups. SOD, CAT and GSH-Px activities, ability to inhibit hydroxyl radical, and GSH contents were decreased, and MDA contents were increased in all groups.
    Title: The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bcl-2-like protein 1
Names
apoptosis regulator Bcl-X
bcl2-L-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025304.1 → NP_001020475.1  bcl-2-like protein 1

    See identical proteins and their annotated locations for NP_001020475.1

    Status: PROVISIONAL

    Source sequence(s)
    U26645
    UniProtKB/Swiss-Prot
    Q07816, Q98908
    Conserved Domains (3) summary
    cd06845
    Location:80 → 190
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:1 → 217
    bcl-2; apoptosis regulator
    pfam02180
    Location:2 → 26
    BH4; Bcl-2 homology region 4

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10357392..10375562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015296319.4 → XP_015151805.1  bcl-2-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q07816, Q98908
    Conserved Domains (3) summary
    cd06845
    Location:80 → 190
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:1 → 217
    bcl-2; apoptosis regulator
    pfam02180
    Location:2 → 26
    BH4; Bcl-2 homology region 4

  2. XM_015296317.4 → XP_015151803.1  bcl-2-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q07816, Q98908
    Related
    ENSGALP00010019864.1, ENSGALT00010033754.1
    Conserved Domains (3) summary
    cd06845
    Location:80 → 190
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:1 → 217
    bcl-2; apoptosis regulator
    pfam02180
    Location:2 → 26
    BH4; Bcl-2 homology region 4

  3. XM_015296318.4 → XP_015151804.1  bcl-2-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q07816, Q98908
    Conserved Domains (3) summary
    cd06845
    Location:80 → 190
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:1 → 217
    bcl-2; apoptosis regulator
    pfam02180
    Location:2 → 26
    BH4; Bcl-2 homology region 4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10139043..10157223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046930549.1 → XP_046786505.1  bcl-2-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q07816, Q98908

  2. XM_046930548.1 → XP_046786504.1  bcl-2-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q07816, Q98908

  3. XM_046930547.1 → XP_046786503.1  bcl-2-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q07816, Q98908
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07816.2 GenPept UniProtKB/Swiss-Prot:Q07816

Gene LinkOut

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