ada2a adenosine deaminase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ada2aprovided by ZNC
Official Full Name: adenosine deaminase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030902-4
See related: Ensembl:ENSDARG00000051746 AllianceGenome:ZFIN:ZDB-GENE-030902-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cecr1; cecr1a; fj65e02; wu:fj65e02
Summary: Predicted to enable several functions, including adenosine deaminase activity; proteoglycan binding activity; and zinc ion binding activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; gill; kidney; liver; and notochord. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: chromosome: 25

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (16689638..16700924)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (16593238..16604524)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2'-deoxyadenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenosine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables deaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in adenosine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adenosine deaminase 2-A

Names: ADA2-1; adenosine deaminase CECR1-A; cat eye syndrome chromosome region, candidate 1; cat eye syndrome chromosome region, candidate 1a; cat eye syndrome critical region protein 1 homolog A

NP_001028889.2

EC 3.5.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033717.2 → NP_001028889.2 adenosine deaminase 2-A precursor

See identical proteins and their annotated locations for NP_001028889.2

Status: PROVISIONAL

Source sequence(s)

AF384217

UniProtKB/Swiss-Prot

P58781, Q7ZVJ3, Q8UVU4

Related

ENSDARP00000067907.5, ENSDART00000073416.6

Conserved Domains (3) summary

cd01321
Location:75 → 494

ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.

TIGR01431
Location:30 → 502

adm_rel; adenosine deaminase-related growth factor

pfam08451
Location:29 → 95

A_deaminase_N; Adenosine/AMP deaminase N-terminal