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pias1.L protein inhibitor of activated STAT 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373715, updated on 4-Nov-2024

Summary

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Official Symbol
pias1.L
Official Full Name
protein inhibitor of activated STAT 1 L homeolog
Primary source
Xenbase:XB-GENE-865622
Locus tag
XELAEV_18018462mg
See related
EnsemblRapid:ENSXLAG00005000784 AllianceGenome:Xenbase:XB-GENE-865622
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gbp; pias; pias1; zmiz3; ddxbp1; xPAIS1; xPIAS1; pias1-A
Summary
Predicted to enable SUMO ligase activity; transcription coregulator activity; and zinc ion binding activity. Predicted to act upstream of or within protein sumoylation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in ectoderm; nervous system; and pharyngeal arch. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pias1.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (124308653..124332294)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (108908528..108932202)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 5 L homeolog Neighboring gene SKI family transcriptional corepressor 1 L homeolog Neighboring gene calmodulin like 4 L homeolog Neighboring gene CLN6, transmembrane ER protein L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82373

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables SUMO ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein inhibitor of activated STAT 1 L homeolog
Names
protein inhibitor of activated STAT, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085692.1 → NP_001079161.1  protein inhibitor of activated STAT 1 L homeolog

    See identical proteins and their annotated locations for NP_001079161.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084084
    UniProtKB/TrEMBL
    A0A974DD81, Q5XHH3
    Related
    ENSXLAP00005002311.1, ENSXLAT00005002357.1
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:330 → 378
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:134 → 270
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    124308653..124332294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018250597.2 → XP_018106086.1  protein inhibitor of activated STAT 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UQU6, A0A974DD81
    Related
    ENSXLAP00005002307.1, ENSXLAT00005002353.1

  2. XM_018250599.2 → XP_018106088.1  protein inhibitor of activated STAT 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UQU6, A0A974DD81

  3. XM_018250598.2 → XP_018106087.1  protein inhibitor of activated STAT 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UQU6, A0A974DD81
Nucleotide Protein Strain
Heading Accession and Version

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