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nbl1.L NBL1, DAN family BMP antagonist L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373697, updated on 4-Nov-2024

Summary

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Official Symbol
nbl1.L
Official Full Name
NBL1, DAN family BMP antagonist L homeolog
Primary source
Xenbase:XB-GENE-865248
Locus tag
XELAEV_18036422mg
See related
EnsemblRapid:ENSXLAG00005015772 AllianceGenome:Xenbase:XB-GENE-865248
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
DAN; no3; nbl1; dand1; nbl1-a
Summary
Predicted to enable BMP binding activity and cytokine activity. Acts upstream of or within determination of dorsal identity. Located in extracellular space. Is expressed in ectoderm; mesenchyme; musculoskeletal system; nervous system; and pharyngeal arch. Orthologous to human NBL1 (NBL1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nbl1.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (136098290..136113563, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (121332664..121336582)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene MGC83681 protein Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled L homeolog Neighboring gene mitochondrial contact site and cristae organizing system subunit 10 L homeolog Neighboring gene capping actin protein of muscle Z-line subunit beta L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Hsu DR, et al. Mol Cell, 1998 Apr. PMID 9660951
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables BMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sequestering of BMP from receptor via BMP binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuroblastoma suppressor of tumorigenicity 1
Names
neuroblastoma 1, DAN family BMP antagonist L homeolog
neuroblastoma, suppression of tumorigenicity 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085679.1 → NP_001079148.1  neuroblastoma suppressor of tumorigenicity 1 precursor

    See identical proteins and their annotated locations for NP_001079148.1

    Status: PROVISIONAL

    Source sequence(s)
    BC074404
    UniProtKB/Swiss-Prot
    O73753
    UniProtKB/TrEMBL
    A0A974HD11
    Related
    ENSXLAP00005046395.1, ENSXLAT00005047499.1
    Conserved Domains (1) summary
    pfam03045
    Location:23 → 121
    DAN; DAN domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    136098290..136113563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O73753.1 GenPept UniProtKB/Swiss-Prot:O73753

Gene LinkOut

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Molecular Biology Databases
Research Materials