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impact.L impact RWD domain protein L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373600, updated on 4-Nov-2024

Summary

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Official Symbol
impact.L
Official Full Name
impact RWD domain protein L homeolog
Primary source
Xenbase:XB-GENE-947996
Locus tag
XELAEV_18031917mg
See related
EnsemblRapid:ENSXLAG00005027455 AllianceGenome:Xenbase:XB-GENE-947996
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
impact; Ximpact; impact-a
Summary
Predicted to enable protein sequestering activity. Predicted to act upstream of or within several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Predicted to be located in cytoplasm. Is expressed in anatomical system and primary germ layer. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See impact.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (116412167..116427725)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (109330686..109346612)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C L homeolog Neighboring gene oxysterol binding protein like 1A L homeolog Neighboring gene histamine receptor H4 gene a1 L homeolog Neighboring gene histamine receptor H4 gene b1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatiotemporal, allelic, and enforced expression of Ximpact, the Xenopus homolog of mouse imprinted gene impact. Yamada Y, et al. Biochem Biophys Res Commun, 1999 Mar 5. PMID 10066441
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein sequestering activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GCN2-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of cytoplasmic translational initiation in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein IMPACT
Names
impact homolog
imprinted and ancient gene protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085599.1 → NP_001079068.1  protein IMPACT

    See identical proteins and their annotated locations for NP_001079068.1

    Status: PROVISIONAL

    Source sequence(s)
    AB020319
    UniProtKB/Swiss-Prot
    Q4KLB3, Q9W625
    UniProtKB/TrEMBL
    A0A974CQ50
    Related
    ENSXLAP00005081596.1, ENSXLAT00005083207.1
    Conserved Domains (2) summary
    smart00591
    Location:15 → 115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:179 → 286
    UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    116412167..116427725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W625.1 GenPept UniProtKB/Swiss-Prot:Q9W625

Gene LinkOut

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