pitx2.S paired like homeodomain 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pitx2.S
Official Full Name: paired like homeodomain 2 S homeolog
Primary source: Xenbase:XB-GENE-6253059
Locus tag: XELAEV_18009341mg
See related: EnsemblRapid:ENSXLAG00005002872 AllianceGenome:Xenbase:XB-GENE-6253059
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pitx2; xPtx2; XPtx2b; pitx2c; xpitx2; XPitx2B; pitx2-a; pitx2-b; pitx2.L
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within animal organ morphogenesis; regulation of transcription by RNA polymerase II; and system development. Predicted to be located in cytoplasm and nucleus. Is expressed in anatomical system and primary germ layer. Human ortholog(s) of this gene implicated in Arts syndrome; Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 1; anterior segment dysgenesis 4; and ring dermoid of cornea. Orthologous to human PITX2 (paired like homeodomain 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1S

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (56647765..56666204)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (56170003..56188602)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ESR1 inhibits the expression of Pitx2 gene by binding to a left side-specific enhancer region in Pitx2 gene and recruiting histone deacetylase 1 to this region, leading to the suppression of Pitx2 gene in the left lateral plate mesoderm.
Title: A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paired like homeodomain 2 S homeolog

Names: homeodomain transcription factor; paired-like homeodomain 2 L homeolog; paired-like homeodomain transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085586.1 → NP_001079055.1 paired like homeodomain 2 S homeolog

See identical proteins and their annotated locations for NP_001079055.1

Status: PROVISIONAL

Source sequence(s)

AJ005787

UniProtKB/Swiss-Prot

Q9PWR3

Conserved Domains (2) summary

pfam00046
Location:90 → 142

Homeobox; Homeobox domain

pfam03826
Location:276 → 293

OAR; OAR domain