JUN Jun proto-oncogene, AP-1 transcription factor subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: JUNprovided by HGNC
Official Full Name: Jun proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
Primary source: HGNC:HGNC:6204
See related: Ensembl:ENSG00000177606 MIM:165160; AllianceGenome:HGNC:6204
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AP1; p39; AP-1; cJUN; c-Jun
Summary: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 1p32.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (58780791..58784047, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (58659236..58662492, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (59246463..59249719, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single cell RNA-seq identifies a FOS/JUN-related monocyte signature associated with clinical response of heart failure patients with mesenchymal stem cell therapy.
Title: Single cell RNA-seq identifies a FOS/JUN-related monocyte signature associated with clinical response of heart failure patients with mesenchymal stem cell therapy.
Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-alpha signaling axis in triple-negative breast cancer.
Title: Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-α signaling axis in triple-negative breast cancer.
ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.
Title: ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.
Homeobox Protein PROX1 Expression is Negatively Regulated by Histone Deacetylase 1 and c-JUN Complex in MDA-MB-231 Human Breast Cancer Cells.
Title: Homeobox Protein PROX1 Expression is Negatively Regulated by Histone Deacetylase 1 and c-JUN Complex in MDA-MB-231 Human Breast Cancer Cells.
Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer.
Title: Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer.
Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.
Title: Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.
Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent AP-1 Pathway Modulation.
Title: Thrombin-Induced COX-2 Expression and PGE(2) Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation.
c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression.
Title: c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression.
LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells.
Title: LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells.
Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis.
Title: Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (812)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection induces basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of jun proto-oncogene (JUN, AP-1) in human B cells	PubMed
	env	HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites	PubMed
	env	The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120	PubMed
	env	HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun	PubMed
	env	Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway	PubMed
	env	HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation	PubMed
	env	Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 induces activation of transcription factor, activated protein-1 (AP-1), comprised of Fos and Jun proteins, in CD4 positive T cell lines	PubMed
Nef	nef	HIV-1 Nef treatment [of SVGA cells] increases phosphorylation of JUN (c-Jun) in SVGA cells	PubMed
	nef	HIV-1 Nef-mediated increase in IL6 expression is enhanced by JUN (AP-1)	PubMed
	nef	Knockdown of C/EBPalpha, C/EBPgamma, and AP-1 by siRNA shows significant reduction of CCL5 levels, suggesting that C/EBPalpha, C/EBPgamma, and AP-1 proteins are involved in Nef-mediated upregulation of CCL5	PubMed
	nef	HIV-1 Nef expression in human (THP-1) monocyte-macrophages induces both DNA binding and transcriptional activities of the activator protein-1 (AP-1) transcription factor, c-fos and c-jun; this induction requires the proline-rich PxxP motif of Nef	PubMed
	nef	HIV-1 Nef inhibits c-jun transcription in mitogen-stimulated human T cells	PubMed
Tat	tat	c-JUN enhances HIV-1 Tat-mediated LTR transcription but suppresses basal LTR transcription in the absence of Tat	PubMed
	tat	HIV-1 Tat induces JUN (AP1) DNA binding activity in CRT-MG cells (as assessed by EMSA) and this activity is enhanced by HDAC6	PubMed
	tat	HIV-1 Tat induces phosphorylation of JUN (AP1) in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat activates AP-1 (c-Jun/c-Fos) activity in human astroglioma cells	PubMed
	tat	HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins	PubMed
	tat	Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2	PubMed
	tat	Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells	PubMed
	tat	HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR	PubMed
	tat	The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) blocks HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppress HIV-1 provirus transcription	PubMed
	tat	HIV-1 Tat interacts with the cooperative rel/AP1 complex, downregulating its transactivation activity and leading to a decrease in IL-2 gene transcription	PubMed
	tat	HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck	PubMed
	tat	Crosslinking experiments suggest a direct binding interaction between HIV-1 Tat and AP1 that is relatively inefficient and that correlates with the ability of AP1 to support Tat transactivation	PubMed
	tat	HIV-1 Tat-induced expression of MCP-1 is partially mediated through the activation of c-jun (Activator Protein-1; AP-1) binding to, and transactivation of the MCP-1 promoter by Tat	PubMed
Vpr	vpr	HIV-1 Vpr involves the JUN (AP-1) transcription factor in the induction of CXCL8 (IL8) in astrocytes	PubMed
	vpr	HIV-1 Vpr involves the JUN (AP-1) transcription factor in the induction of IL6 in astrocytes	PubMed
	vpr	HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes	PubMed
	vpr	Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages.	PubMed
Vpu	vpu	HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68404 (e-PCR)
- UniSTS:27398

PMC133732P5 (e-PCR)
- UniSTS:270645

PMC151710P1 (e-PCR)
- UniSTS:271167

G15909 (e-PCR)
- UniSTS:67157

D5Lev15 (e-PCR)
- UniSTS:239709

RH68524 (e-PCR)
- UniSTS:33675

JUN_454 (e-PCR)
- UniSTS:277400

PMC153970P1 (e-PCR)
- UniSTS:271278

D1S3319 (e-PCR)
- UniSTS:57793

PMC55707P1 (e-PCR)
- UniSTS:273351

PMC129043P1 (e-PCR)
- UniSTS:270580

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables R-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	HDA more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cAMP response element binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables general transcription initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrated stress response signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation by host of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in release from viral latency	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	ISA Inferred from Sequence Alignment more info
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear chromosome	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transcription factor AP-1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor AP-1 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription factor AP-1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor Jun

Names: Jun activation domain binding protein; activator protein 1; enhancer-binding protein AP1; jun oncogene; proto-oncogene c-Jun; proto-oncogene cJun; transcription factor AP-1; transcription factor AP-1 subunit Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047027.2 RefSeqGene

Range

5000..8256

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002228.4 → NP_002219.1 transcription factor Jun

See identical proteins and their annotated locations for NP_002219.1

Status: REVIEWED

Source sequence(s)

AL136985

Consensus CDS

CCDS610.1

UniProtKB/Swiss-Prot

P05412, Q6FHM7, Q96G93

UniProtKB/TrEMBL

Q6FHK0

Related

ENSP00000360266.2, ENST00000371222.4

Conserved Domains (2) summary

cd14696
Location:254 → 314

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam03957
Location:5 → 241

Jun; Jun-like transcription factor