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botv brother of tout-velu [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37198, updated on 2-Nov-2024

Summary

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Official Symbol
botvprovided by FlyBase
Official Full Name
brother of tout-veluprovided by FlyBase
Primary source
FLYBASE:FBgn0027535
Locus tag
Dmel_CG15110
See related
AllianceGenome:FB:FBgn0027535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD21192; Botv; CG15110; dExt3; DExt3; DEXT3; Dextl3; DEXTL3; Dmel\CG15110; Extl3; EXTL3
Summary
Enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparan sulfate proteoglycan metabolic process; and heparin biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including ganglia; head; larval visceral muscle cell; mesoderm; and visceral muscle primordium. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See botv in Genome Data Viewer
Location:
56B5-56B5; 2-88 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19129589..19133706)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15017094..15021211)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1A Neighboring gene Ionotropic receptor 56a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of novel alleles of brother of tout-velu, the drosophila ortholog of human EXTL3 using a newly developed FRT42D ovo(D) chromosome. Lujan E, et al. Genesis, 2016 Nov. PMID 27636555, Free PMC Article
  2. Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation. Kim BT, et al. J Biol Chem, 2002 Apr 19. PMID 11832488
  3. Heparan sulfate polymerization in Drosophila. Izumikawa T, et al. J Biol Chem, 2006 Jan 27. PMID 16303756
  4. Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin. He BZ, et al. Genetics, 2014 Feb. PMID 24281155, Free PMC Article
  5. Heparan sulfate proteoglycans regulate autophagy in Drosophila. Reynolds-Peterson CE, et al. Autophagy, 2017 Aug 3. PMID 28402693, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. To establish the developmental relevance of this reagent we characterized the maternal-effect phenotypes of novel brother of tout-velu alleles generated on an FRT42D chromosome in a somatic mosaic screen. We find that an apparent null mutation that causes severe defects in somatic tissues has a much milder effect on embryonic patterning, emphasizing the necessity of analyzing mutant phenotypes at multiple developmental st
    Title: Analysis of novel alleles of brother of tout-velu, the drosophila ortholog of human EXTL3 using a newly developed FRT42D ovo(D) chromosome.
  2. Results suggest that all three Drosophila EXT proteins -- tout-velu, brother of tout-velu, and sister of tout-velu -- are required for the biosynthesis of heparan sulfate proteoglycans, and for the gradient formation of morphogens.
    Title: Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.
  3. Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.
    Title: Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycosaminoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
brother of tout-velu
Names
CG15110-PA
botv-PA
brother of tout velu
brother of tout-velo
brother of ttv
brother-of-tout-velu
drosophila Ext-like 3
NP_523790.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19129589..19133706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079066.3 → NP_523790.1  brother of tout-velu [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523790.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XZ08
    Related
    FBpp0085763
    Conserved Domains (3) summary
    pfam03016
    Location:224 → 551
    Exostosin; Exostosin family
    pfam07106
    Location:107 → 185
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    pfam09258
    Location:714 → 949
    Glyco_transf_64; Glycosyl transferase family 64 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XZ08.1 Q9XZ08

Gene LinkOut

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