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5-HT1A 5-hydroxytryptamine (serotonin) receptor 1A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37196, updated on 2-Nov-2024

Summary

Official Symbol
5-HT1Aprovided by FlyBase
Official Full Name
5-hydroxytryptamine (serotonin) receptor 1Aprovided by FlyBase
Primary source
FLYBASE:FBgn0004168
Locus tag
Dmel_CG16720
See related
AllianceGenome:FB:FBgn0004168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5-HT; 5-HT-1a; 5-HT-dro2A; 5-HT1a; 5-HT1ADro; 5-HT[1A]Dro; 5-HT[[1ADro]]; 5-HT[[1A]]; 5-HT[[1A]]DRO; 5HT; 5HT-1A; 5HT-dro2A; 5HT-drp[[2A]]; 5HT-R2A; 5HT1a; 5HT1A; 5htdro2a; 5HT[[1ADro]]; CG16720; d5-HT1A; Dm5-HT1A; Dm5-HT[[1A]]; Dm5HTdro2A; Dmel\CG16720; DRO2A; HT1A
Summary
Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled serotonin receptor signaling pathway; anesthesia-resistant memory; and inter-male aggressive behavior. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including adult brain; adult head; larval midline neurons; neurosecretory cell of brain; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; anxiety disorder (multiple); depressive disorder (multiple); and substance abuse (multiple). Orthologous to several human genes including HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See 5-HT1A in Genome Data Viewer
Location:
56B2-56B5; 2-88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19067155..19121958)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14954660..15009463)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione peroxidase-like Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 56a Neighboring gene uncharacterized protein Neighboring gene brother of tout-velu

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled amine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled serotonin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables G protein-coupled serotonin receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables Gi/o-coupled serotonin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in anesthesia-resistant memory IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inter-male aggressive behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipase C-activating serotonin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in serotonin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
5-hydroxytryptamine (serotonin) receptor 1A
Names
5-HT1A-PB
5-HT1A-PC
CG16720-PB
CG16720-PC
serotonin receptor 1A
serotonin receptor 2A
serotonin-receptor-2A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19067155..19121958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001369983.1NP_001356890.1  5-hydroxytryptamine (serotonin) receptor 1A, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28285, Q0E921, Q4QQC9, Q5MTE9, Q5MTF1, Q5MTF2, Q5MTF3, Q5MTF8, Q5MTF9, Q5MTG0, Q5MTG1, Q5MTG2, Q5MTG3, Q5MTG4, Q5MTG6, Q5MTG9, Q5MTH1, Q5MTH2, Q5MTH5, Q5MTH6, Q5MTH7, Q5MTH9, Q5MTI0, Q5MTI1
    Conserved Domains (3) summary
    cd15331
    Location:227413
    7tmA_5-HT1A_invertebrates; serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:747772
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:743816
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_166322.2NP_725849.1  5-hydroxytryptamine (serotonin) receptor 1A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725849.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28285, Q0E921, Q4QQC9, Q5MTE9, Q5MTF1, Q5MTF2, Q5MTF3, Q5MTF8, Q5MTF9, Q5MTG0, Q5MTG1, Q5MTG2, Q5MTG3, Q5MTG4, Q5MTG6, Q5MTG9, Q5MTH1, Q5MTH2, Q5MTH5, Q5MTH6, Q5MTH7, Q5MTH9, Q5MTI0, Q5MTI1
    Related
    FBpp0085761
    Conserved Domains (1) summary
    pfam00001
    Location:243413
    7tm_1; 7 transmembrane receptor (rhodopsin family)