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Mctp Multiple C2 domain and transmembrane region protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37165, updated on 18-Sep-2024

Summary

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Official Symbol
Mctpprovided by FlyBase
Official Full Name
Multiple C2 domain and transmembrane region proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034389
Locus tag
Dmel_CG15078
See related
AllianceGenome:FB:FBgn0034389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15078; CG33146; CG33148; Dmel\CG15078; DmMCTP; mctp
Summary
Enables calcium ion binding activity. Involved in regulation of neuronal synaptic plasticity and regulation of neurotransmitter secretion. Located in endoplasmic reticulum membrane. Is expressed in adult head; olfactory sensory organ; and organism. Orthologous to several human genes including MCTP1 (multiple C2 and transmembrane domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Mctp in Genome Data Viewer
Location:
55F1-55F2; 2-86 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18761758..18774824)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14649263..14662329)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-A Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12b2 Neighboring gene jabba Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene antisense RNA:CR43964 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity. Genç Ö, et al. Elife, 2017 May 9. PMID 28485711, Free PMC Article
  2. Epistatic selection on a selfish Segregation Distorter supergene - drive, recombination, and genetic load. Navarro-Dominguez B, et al. Elife, 2022 Apr 29. PMID 35486424, Free PMC Article
  3. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. Shin OH, et al. J Biol Chem, 2005 Jan 14. PMID 15528213
  4. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article
  5. A screen for genes expressed in the olfactory organs of Drosophila melanogaster identifies genes involved in olfactory behaviour. Tunstall NE, et al. PLoS One, 2012. PMID 22530061, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
multiple C2 domain and transmembrane region protein
Names
CG15078-PA
CG15078-PB
CG15078-PD
CG15078-PE
CG15078-PF
CG15078-PG
Mctp-PA
Mctp-PB
Mctp-PD
Mctp-PE
Mctp-PF
Mctp-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18761758..18774824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299661.1 → NP_001286590.1  multiple C2 domain and transmembrane region protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286590.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZBD6
    Conserved Domains (4) summary
    cd04042
    Location:218 → 338
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:371 → 478
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:518 → 639
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:770 → 874
    PRT_C; Plant phosphoribosyltransferase C-terminal

  2. NM_001274149.1 → NP_001261078.1  multiple C2 domain and transmembrane region protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261078.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZBD6
    Conserved Domains (4) summary
    cd04042
    Location:237 → 357
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:390 → 497
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:537 → 658
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:789 → 893
    PRT_C; Plant phosphoribosyltransferase C-terminal

  3. NM_001316428.1 → NP_001303357.1  multiple C2 domain and transmembrane region protein, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KEZ6, A0A0C4DHG8, A0A126GUP9, A1ZBD6
    Conserved Domains (4) summary
    cd04042
    Location:237 → 357
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:390 → 497
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:537 → 658
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:789 → 893
    PRT_C; Plant phosphoribosyltransferase C-terminal

  4. NM_137528.5 → NP_611372.3  multiple C2 domain and transmembrane region protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611372.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZBD6
    Conserved Domains (4) summary
    cd04042
    Location:218 → 338
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:371 → 478
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:518 → 639
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:770 → 874
    PRT_C; Plant phosphoribosyltransferase C-terminal

  5. NM_001043094.2 → NP_001036559.2  multiple C2 domain and transmembrane region protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036559.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZBD6
    Conserved Domains (4) summary
    cd04042
    Location:279 → 399
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:432 → 539
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:579 → 700
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:831 → 935
    PRT_C; Plant phosphoribosyltransferase C-terminal

  6. NM_001043095.3 → NP_001036560.1  multiple C2 domain and transmembrane region protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036560.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZN2
    Conserved Domains (3) summary
    cd08376
    Location:74 → 181
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:221 → 342
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:473 → 577
    PRT_C; Plant phosphoribosyltransferase C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBD6.3 A1ZBD6
Q7JZN2 Q7JZN2

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