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Cyp12b2 Cytochrome P450 12b2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37163, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp12b2provided by FlyBase
Official Full Name
Cytochrome P450 12b2provided by FlyBase
Primary source
FLYBASE:FBgn0034387
Locus tag
Dmel_CG15077
See related
AllianceGenome:FB:FBgn0034387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12b2; CG15077; Cyp12B2; Dmel\CG15077
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval tracheal section. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cyp12b2 in Genome Data Viewer
Location:
55F1-55F1; 2-86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18754995..18757083)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14642500..14644588)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene jabba Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene Multiple C2 domain and transmembrane region protein Neighboring gene antisense RNA:CR43964 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene Regulatory Variation in Drosophila melanogaster Renal Tissue. Glaser-Schmitt A, et al. Genetics, 2018 Sep. PMID 29976765, Free PMC Article
  2. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
  3. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article
  4. Regulation of cytochrome P450 expression in Drosophila: Genomic insights. Giraudo M, et al. Pestic Biochem Physiol, 2010 Jun 1. PMID 20582327, Free PMC Article
  5. The molecular evolution of cytochrome P450 genes within and between drosophila species. Good RT, et al. Genome Biol Evol, 2014 Apr 20. PMID 24751979, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 12b2
Names
CG15077-PA
Cyp12b2-PA
NP_611370.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18754995..18757083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137526.3 → NP_611370.2  cytochrome P450 12b2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611370.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V474, Q9V8M2
    Conserved Domains (1) summary
    cl12078
    Location:59 → 511
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V8M2.2 Q9V8M2

Gene LinkOut

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