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Hs3st-A Heparan sulfate 3-O sulfotransferase-A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37161, updated on 18-Sep-2024

Summary

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Official Symbol
Hs3st-Aprovided by FlyBase
Official Full Name
Heparan sulfate 3-O sulfotransferase-Aprovided by FlyBase
Primary source
FLYBASE:FBgn0053147
Locus tag
Dmel_CG33147
See related
AllianceGenome:FB:FBgn0053147
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15074; CG15075; CG15076; CG30123; CG30124; CG33147; dHS3OSTA; Dmel\CG33147; HS3ST; lincRNA.S3111
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Is expressed in several structures, including dorsal sensory complex proper primordium; embryonic/larval nervous system; extended germ band embryo; presumptive embryonic/larval system; and procephalic segment. Orthologous to several human genes including HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Hs3st-A in Genome Data Viewer
Location:
55E9-55F1; 2-86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18718114..18754675)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14605619..14642180)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR33942 Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 51 Neighboring gene mir-4982 stem loop Neighboring gene Lithium-inducible SLC6 transporter Neighboring gene long non-coding RNA:CR30121 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12b2 Neighboring gene jabba Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene Multiple C2 domain and transmembrane region protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila heparan sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling. Guo Y, et al. J Genet Genomics, 2014 Jul 20. PMID 25064676
  2. A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila. Kasuya J, et al. Neuroscience, 2009 Oct 20. PMID 19619614, Free PMC Article
  3. The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression. Melnikova L, et al. Sci Rep, 2019 Mar 29. PMID 30926937, Free PMC Article
  4. Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut. Guo Y, et al. Cell Signal, 2014 Nov. PMID 25049075
  5. Heparan sulfate proteoglycans in Drosophila neuromuscular development. Kamimura K, et al. Biochim Biophys Acta Gen Subj, 2017 Oct. PMID 28645846

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
heparan sulfate 3-O sulfotransferase-A
Names
CG33147-PA
CG33147-PB
Hs3st-A-PA
Hs3st-A-PB
NP_001286589.1
NP_788409.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18718114..18754675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299660.1 → NP_001286589.1  heparan sulfate 3-O sulfotransferase-A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286589.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRE7, Q9V8M0
    Conserved Domains (1) summary
    cl21551
    Location:242 → 587
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_176229.3 → NP_788409.1  heparan sulfate 3-O sulfotransferase-A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRE7, Q9V8M0
    Related
    FBpp0085791
    Conserved Domains (1) summary
    cl21551
    Location:242 → 587
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRE7 Q8MRE7
Q9V8L9 Q9V8L9

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