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Sec6 Secretory 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37142, updated on 18-Sep-2024

Summary

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Official Symbol
Sec6provided by FlyBase
Official Full Name
Secretory 6provided by FlyBase
Primary source
FLYBASE:FBgn0266671
Locus tag
Dmel_CG5341
See related
AllianceGenome:FB:FBgn0266671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5341; Dmel\CG5341; dsec6; Dsec6; sec 6; sec6; Sec6p
Summary
Predicted to enable SNARE binding activity. Involved in several processes, including border follicle cell migration; rhabdomere membrane biogenesis; and vesicle-mediated transport to the plasma membrane. Located in several cellular components, including cytoplasm; rhabdomere; and zonula adherens. Part of exocyst. Is expressed in several structures, including adult head; embryonic/larval digestive system; embryonic/larval garland cell; germ layer derivative; and spermatid cyst. Orthologous to several human genes including EXOC3 (exocyst complex component 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Sec6 in Genome Data Viewer
Location:
55E2-55E2; 2-86 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18625249..18627718)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14512754..14515223)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 7 Neighboring gene uncharacterized protein Neighboring gene Cystathionine gamma-lyase Neighboring gene zonda

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dendrite regeneration mediates functional recovery after complete dendrite removal. Hertzler JI, et al. Dev Biol, 2023 May. PMID 36870669, Free PMC Article
  2. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Juhász G, et al. Genes Dev, 2007 Dec 1. PMID 18056421, Free PMC Article
  3. Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization. Yatsenko AS, et al. Elife, 2021 Feb 23. PMID 33620318, Free PMC Article
  4. dSTIM- and Ral/Exocyst-Mediated Synaptic Release from Pupal Dopaminergic Neurons Sustains Drosophila Flight. Richhariya S, et al. eNeuro, 2018 May-Jun. PMID 29938216, Free PMC Article
  5. Three mechanisms control E-cadherin localization to the zonula adherens. Woichansky I, et al. Nat Commun, 2016 Mar 10. PMID 26960923, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sec6 is an exocyst complex component believed to bind secretory vesicles to plasma membrane sites. Sec6 mutations cause cell death and disrupt plasma membrane growth. In developing photoreceptor cells (PRCs) Sec6 shows accumulation at adherens junctions
    Title: Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.
  2. Sec5, Sec6 and Sec8 act as a complex, each member dependent on the others for proper localization and function
    Title: Sec6 mutations and the Drosophila exocyst complex.
  3. The Drosophila exocyst component sec6 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane.
    Title: Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in plasma membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle docking NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle targeting NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in zonula adherens IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secretory 6
Names
CG5341-PA
Sec6 ortholog
Sec6-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18625249..18627718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137507.5 → NP_611351.1  secretory 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611351.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TT4, Q9V8K2
    Related
    FBpp0085888
    Conserved Domains (1) summary
    pfam06046
    Location:179 → 731
    Sec6; Exocyst complex component Sec6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V8K2.2 Q9V8K2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
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