stau staufen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stauprovided by FlyBase
Official Full Name: staufenprovided by FlyBase
Primary source: FLYBASE:FBgn0003520
Locus tag: Dmel_CG5753
See related: AllianceGenome:FB:FBgn0003520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5753; Dmel\CG5753; Dmstau; dStau; Stau; STAU; Stau1; Stauf; Staufen
Summary: Enables mRNA 3'-UTR binding activity. Involved in several processes, including pole plasm assembly; positive regulation of cellular component biogenesis; and regulation of pole plasm oskar mRNA localization. Located in several cellular components, including basal cortex; cytoplasmic ribonucleoprotein granule; and subsynaptic reticulum. Part of messenger ribonucleoprotein complex. Is expressed in several structures, including extended germ band embryo; neuromuscular junction; ovariole; presumptive embryonic/larval system; and trunk ectoderm. Orthologous to human STAU1 (staufen double-stranded RNA binding protein 1) and STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 55B5-55B7; 2-84 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18117896..18125779, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14005401..14013284, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
Title: C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.
Title: Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.
Study shows that double-stranded RNA binding domains (dsRBDs) 1 and 2 of mStau2 bind RNA with similar affinities and kinetics as dsRBDs 3 and 4. While RNA binding by these tandem domains is transient, all four dsRBDs recognize their target RNAs with high stability. Rescue experiments in Drosophila oocytes demonstrate that mStau2 partially rescues dmStau-dependent mRNA localization.
Title: Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
The role of Miranda in the localization of Staufen during the division of neuroblasts is described.
Title: The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division.
Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number.
Title: Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number.
the expression of Adf-1 targets Staufen and Fasciclin II (FasII), identified through larval brain ChIP-Seq for Adf-1, is negatively regulated by Adf-1, and manipulations of these genes predictably modify dendrite growth.
Title: The Drosophila transcription factor Adf-1 (nalyot) regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity.
Data propose bicoid mRNA localization was done by Swallow indirectly organizing the cytoskeleton, whereas Staufen plays a direct role in dynein-dependent bicoid mRNA transport.
Title: Distinguishing direct from indirect roles for bicoid mRNA localization factors.
establishment of developmental precision and proportions in the early Drosophila embryo
Title: Establishment of developmental precision and proportions in the early Drosophila embryo.
role in long-term memory
Title: The staufen/pumilio pathway is involved in Drosophila long-term memory.
Miranda has a role in coupling oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway
Title: Miranda couples oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables double-stranded RNA binding	TAS Traceable Author Statement more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior axis specification, embryo	IGI Inferred from Genetic Interaction more info	PubMed
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric protein localization involved in cell fate determination	TAS Traceable Author Statement more info	PubMed
involved_in bicoid mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	TAS Traceable Author Statement more info	PubMed
involved_in oogenesis	TAS Traceable Author Statement more info	PubMed
involved_in pole plasm RNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic mRNA processing body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oskar mRNA translation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal cortex	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in germ plasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in posterior cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in subsynaptic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: staufen

Names: CG5753-PA; CG5753-PB; CG5753-PC; stau-PA; stau-PB; stau-PC; stauffen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18117896..18125779 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057403.4 → NP_476751.1 staufen, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476751.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25159, Q6NQY8, Q86PB7, Q9V8B8, Q9V8B9

Related

FBpp0085962

Conserved Domains (3) summary

smart00358
Location:579 → 644

DSRM; Double-stranded RNA binding motif

pfam16482
Location:953 → 1020

Staufen_C; Staufen C-terminal domain

cl00054
Location:529 → 555

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_166263.2 → NP_725748.1 staufen, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725748.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25159

Related

FBpp0085963

Conserved Domains (3) summary

smart00358
Location:467 → 532

DSRM; Double-stranded RNA binding motif

pfam16482
Location:841 → 908

Staufen_C; Staufen C-terminal domain

cl00054
Location:417 → 443

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
NM_001169714.2 → NP_001163185.1 staufen, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163185.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JGK6

Conserved Domains (3) summary

smart00358
Location:579 → 644

DSRM; Double-stranded RNA binding motif

pfam16482
Location:952 → 1019

Staufen_C; Staufen C-terminal domain

cl00054
Location:529 → 555

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...