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ACOX1 acyl-CoA oxidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37028, updated on 19-Jun-2024

Summary

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Official Symbol
ACOX1provided by FlyBase
Official Full Name
acyl-CoA oxidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0027572
Locus tag
Dmel_CG5009
See related
AllianceGenome:FB:FBgn0027572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH07485; CG5009; dACOX1; Dmel\CG5009; GH07485
Summary
Enables protein homodimerization activity. Involved in hydrogen peroxide biosynthetic process and very long-chain fatty acid beta-oxidation. Predicted to be active in peroxisome. Is expressed in adult heart; anlage in statu nascendi; glial cell; trunk mesoderm; and trunk mesoderm anlage. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6 and peroxisomal acyl-CoA oxidase deficiency. Orthologous to several human genes including ACOX1 (acyl-CoA oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ACOX1 in Genome Data Viewer
Location:
54E8-54E8; 2-84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17760940..17764541)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13648445..13652046)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sarcosine dehydrogenase Neighboring gene HLH54F Neighboring gene Oligosaccharide transferase Delta subunit Neighboring gene antisense RNA:CR44416 Neighboring gene mir-3643 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. Chung HL, et al. Neuron, 2020 May 20. PMID 32169171, Free PMC Article
  2. Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms. Chen X, et al. BMC Genomics, 2012 Feb 14. PMID 22333271, Free PMC Article
  3. CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect. Champer J, et al. Genetics, 2019 May. PMID 30918006, Free PMC Article
  4. miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. Pandey M, et al. Elife, 2021 Jun 8. PMID 34100717, Free PMC Article
  5. HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of Drosophila. Ismat A, et al. Development, 2010 Sep. PMID 20736287, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.
    Title: Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in generation of precursor metabolites and energy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hydrogen peroxide biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in prostaglandin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in very long-chain fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
acyl-CoA oxidase 1
Names
ACOX1-PA
CG5009-PA
NP_611264.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17760940..17764541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137420.3 → NP_611264.2  acyl-CoA oxidase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611264.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KML2, Q95ST5
    UniProtKB/TrEMBL
    B5RIN5
    Related
    FBpp0088517
    Conserved Domains (2) summary
    cd01150
    Location:8 → 645
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02443
    Location:10 → 669
    PLN02443; acyl-coenzyme A oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KML2.1 Q7KML2

Gene LinkOut

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