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MESR4 Misexpression suppressor of ras 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36986, updated on 22-Aug-2024

Summary

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Official Symbol
MESR4provided by FlyBase
Official Full Name
Misexpression suppressor of ras 4provided by FlyBase
Primary source
FLYBASE:FBgn0034240
Locus tag
Dmel_CG4903
See related
AllianceGenome:FB:FBgn0034240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4903; Dmel\CG4903; EP(2)0988; EP0386; EP0988; EP988; mesr4; Mesr4; MSR4
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular lipid metabolic process; cellular response to hypoxia; and germarium-derived oocyte differentiation. Located in nucleus. Is expressed in several structures, including anterior endoderm; embryonic brain; embryonic/larval midgut; extended germ band embryo; and germline cell. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See MESR4 in Genome Data Viewer
Location:
54C3-54C5; 2-83 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17547769..17556289)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13435274..13443794)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene cyclophilin-33 Neighboring gene Ribosomal protein L18A Neighboring gene Kinesin-like protein at 54D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plant homeodomain finger protein MESR4 is essential for embryonic development in Drosophila. Seong KH, et al. Genesis, 2015 Nov. PMID 26467775
  2. Drosophila MESR4 Gene Ensures Germline Stem Cell Differentiation by Promoting the Transcription of bag of marbles. Szarka-Kovács AB, et al. Cells, 2022 Jun 28. PMID 35805140, Free PMC Article
  3. A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function. Wissel S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27280787, Free PMC Article
  4. Identification of a novel role for Drosophila MESR4 in lipid metabolism. Tsuda-Sakurai K, et al. Genes Cells, 2015 Apr. PMID 25639854
  5. A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Huang AM, et al. Genetics, 2000 Nov. PMID 11063696, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of MESR4 in germline cell differentiation
    Title: A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.
  2. results suggested that MESR4 is a novel chromatin-binding protein required for proper expression of genes including those regulated by the EGFR signaling pathway during development
    Title: The plant homeodomain finger protein MESR4 is essential for embryonic development in Drosophila.
  3. MESR4 reduces lipid accumulation in the fat body, whereas MESR4 knockdown increases it. MESR4 up-regulates the expression of major lipases, which may account for the reduction in lipid storage in the fat body and the release of free fatty acids.
    Title: Identification of a novel role for Drosophila MESR4 in lipid metabolism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived oocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
misexpression suppressor of ras 4
Names
CG4903-PA
CG4903-PB
CG4903-PC
CG4903-PD
MESR4-PA
MESR4-PB
MESR4-PC
MESR4-PD
misexpression of Ras 4
misexpression suppressor of Ras4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17547769..17556289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103889.2 → NP_001097359.1  misexpression suppressor of ras 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097359.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAV3
    Conserved Domains (3) summary
    sd00017
    Location:1272 → 1288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1295 → 1315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd15505
    Location:2110 → 2156
    PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family

  2. NM_001299608.1 → NP_001286537.1  misexpression suppressor of ras 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286537.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFV9
    Conserved Domains (3) summary
    sd00017
    Location:1270 → 1286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1293 → 1313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd15505
    Location:2108 → 2154
    PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family

  3. NM_079051.4 → NP_523775.2  misexpression suppressor of ras 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523775.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAV3
    Related
    FBpp0086102
    Conserved Domains (3) summary
    sd00017
    Location:1272 → 1288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1295 → 1315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd15505
    Location:2110 → 2156
    PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family

  4. NM_001299609.1 → NP_001286538.1  misexpression suppressor of ras 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286538.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGV3
    Conserved Domains (3) summary
    sd00017
    Location:1252 → 1268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1275 → 1295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd15505
    Location:2090 → 2136
    PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFV9 A0A0B4LFV9
A0A0B4LGV3 A0A0B4LGV3
A1ZAV3 A1ZAV3
Q9GU55 Q9GU55

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