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tef teflon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36920, updated on 2-Nov-2024

Summary

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Official Symbol
tefprovided by FlyBase
Official Full Name
teflonprovided by FlyBase
Primary source
FLYBASE:FBgn0086350
Locus tag
Dmel_CG8961
See related
AllianceGenome:FB:FBgn0086350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8961; Dmel\CG8961; l(2)k15914
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in male meiosis I and male meiosis chromosome separation. Located in autosome. Is expressed in organism. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tef in Genome Data Viewer
Location:
53F2-53F2; 2-81 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17054546..17056835, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12942051..12944340, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 6 Neighboring gene uncharacterized protein Neighboring gene fat-spondin Neighboring gene uncharacterized protein Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The teflon gene is required for maintenance of autosomal homolog pairing at meiosis I in male Drosophila melanogaster. Tomkiel JE, et al. Genetics, 2001 Jan. PMID 11139508, Free PMC Article
  2. From early homologue recognition to synaptonemal complex formation. Zickler D. Chromosoma, 2006 Jun. PMID 16570189
  3. Sex Chromosome Pairing Mediated by Euchromatic Homology in Drosophila Male Meiosis. Hylton CA, et al. Genetics, 2020 Mar. PMID 31915134, Free PMC Article
  4. When size does not matter: pairing sites during meiosis. McKim KS. Cell, 2005 Dec 16. PMID 16360029
  5. Uncharted territories: Solving the mysteries of male meiosis in flies. Lee L, et al. PLoS Genet, 2024 Mar. PMID 38489251, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for Tef as a bridging molecule that holds autosome bivalents together via heterochromatic connections.
    Title: Molecular characterization of teflon, a gene required for meiotic autosome segregation in male Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in autosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
teflon
Names
CG8961-PA
lethal (2) k15914
tef-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17054546..17056835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079042.4 → NP_523766.1  teflon [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6UYC2, B6UYC7, B6UYC8, B6UYD0, B6UYD1, B6UYD2, B6UYD3, B6UYD5, B6UYD6, B6UYD8, B6UYE0, B6UYE5, B6UYE6, B6UYE9, B6UYF1, B6UYF2, B6UYF3, Q5MBE0, Q7K4M4
    Related
    FBpp0086165
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K4M4.1 Q7K4M4

Gene LinkOut

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