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adat3 adenosine deaminase tRNA specific 3 [ Danio rerio (zebrafish) ]

Gene ID: 368634, updated on 17-Aug-2024

Summary

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Official Symbol
adat3provided by ZNC
Official Full Name
adenosine deaminase tRNA specific 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-531
See related
Ensembl:ENSDARG00000005640 AllianceGenome:ZFIN:ZDB-GENE-030616-531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:103555; si:dz72b14.5; si:dkey-204g5.2; si:busm1-72b14.5
Summary
Predicted to enable catalytic activity and metal ion binding activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to act upstream of or within tRNA processing. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See adat3 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (41035925..41040492, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (41234138..41238705, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene ORMDL sphingolipid biosynthesis regulator 1 Neighboring gene O-sialoglycoprotein endopeptidase-like 1 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene zgc:136439 Neighboring gene asparagine synthetase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC103555

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to tRNA-specific adenosine-34 deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable inactive tRNA-specific adenosine deaminase-like protein 3
Names
tRNA-specific adenosine-34 deaminase subunit adat3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005300.3 → NP_001005300.2  probable inactive tRNA-specific adenosine deaminase-like protein 3

    See identical proteins and their annotated locations for NP_001005300.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT737230
    UniProtKB/Swiss-Prot
    B0V342, Q8JFR8, Q8JFW4
    UniProtKB/TrEMBL
    A0A8M1P0S6, Z4YHM2
    Related
    ENSDARP00000018770.5, ENSDART00000008275.8
    Conserved Domains (1) summary
    COG0590
    Location:167 → 336
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

  2. NM_001293177.1 → NP_001280106.1  probable inactive tRNA-specific adenosine deaminase-like protein 3

    See identical proteins and their annotated locations for NP_001280106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT737230
    UniProtKB/Swiss-Prot
    B0V342, Q8JFR8, Q8JFW4
    UniProtKB/TrEMBL
    A0A8M1P0S6, Z4YHM2
    Related
    ENSDARP00000137501.1, ENSDART00000163164.2
    Conserved Domains (1) summary
    COG0590
    Location:167 → 336
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    41035925..41040492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JFW4.2 GenPept UniProtKB/Swiss-Prot:Q8JFW4

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