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Amyrel Amylase related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36863, updated on 2-Nov-2024

Summary

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Official Symbol
Amyrelprovided by FlyBase
Official Full Name
Amylase relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0020506
Locus tag
Dmel_CG8221
See related
AllianceGenome:FB:FBgn0020506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
amyrel; AmyRel; CG8221; Dmel\CG8221; melrel
Summary
Enables 4-alpha-glucanotransferase activity and alpha-amylase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in extracellular space. Orthologous to human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Amyrel in Genome Data Viewer
Location:
53C14-53C14; 2-80 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16651095..16652699, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12538600..12540204, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Anaplastic lymphoma kinase Neighboring gene gprs Neighboring gene nach Neighboring gene picot

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polyphyly of the Zaprionus genus group (Diptera: Drosophilidae). Yassin A, et al. Mol Phylogenet Evol, 2010 Apr. PMID 19761854
  2. Amyrel, a novel glucose-forming α-amylase from Drosophila with 4-α-glucanotransferase activity by disproportionation and hydrolysis of maltooligosaccharides. Feller G, et al. Glycobiology, 2021 Sep 20. PMID 33978737
  3. A single amino-acid substitution toggles chloride dependence of the alpha-amylase paralog amyrel in Drosophila melanogaster and Drosophila virilis species. Claisse G, et al. Insect Biochem Mol Biol, 2016 Aug. PMID 27312592
  4. Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. Ambrosio L, et al. PLoS One, 2014. PMID 25133712, Free PMC Article
  5. Divergence between Drosophila santomea and allopatric or sympatric populations of D. yakuba using paralogous amylase genes and migration scenarios along the Cameroon volcanic line. Cariou ML, et al. Mol Ecol, 2001 Mar. PMID 11298976

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Amyrel, a novel glucose-forming alpha-amylase from Drosophila with 4-alpha-glucanotransferase activity by disproportionation and hydrolysis of maltooligosaccharides.
    Title: Amyrel, a novel glucose-forming α-amylase from Drosophila with 4-α-glucanotransferase activity by disproportionation and hydrolysis of maltooligosaccharides.
  2. Amylolytic activity of Amyrel is about thirty times weaker than the classical Drosophila alpha-amylase, and the substitution of the arginine by a glutamine in D. melanogaster suppressed the chloride-dependence but was detrimental to activity. In contrast, changing the glutamine into an arginine rendered D. virilis Amyrel chloride-dependent, and interestingly, significantly increased its catalytic efficiency.
    Title: A single amino-acid substitution toggles chloride dependence of the alpha-amylase paralog amyrel in Drosophila melanogaster and Drosophila virilis species.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 4-alpha-glucanotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-amylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-amylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-amylase activity IEA
Inferred from Electronic Annotation
more info
  
enables amylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
amylase related
Names
Amyrel-PA
CG8221-PA
amyrel
NP_477262.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16651095..16652699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057914.4 → NP_477262.1  amylase related [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477262.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18408, Q9V7S3
    Related
    FBpp0086263
    Conserved Domains (2) summary
    cd11317
    Location:29 → 398
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:404 → 492
    Aamy_C; Aamy_C domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18408.2 O18408

Gene LinkOut

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