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lbr lamin B receptor [ Danio rerio (zebrafish) ]

Gene ID: 368360, updated on 2-Nov-2024

Summary

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Official Symbol
lbrprovided by ZNC
Official Full Name
lamin B receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030804-11
See related
Ensembl:ENSDARG00000014013 AllianceGenome:ZFIN:ZDB-GENE-030804-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb406; zgc:86649; wu:fb75h08; wu:fc47b04; wu:fd36b07
Summary
Predicted to enable delta14-sterol reductase activity. Acts upstream of or within cell migration involved in gastrulation. Located in nuclear inner membrane. Is expressed in several structures, including hypochord; nervous system; neural plate; optic vesicle; and tail bud. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See lbr in Genome Data Viewer
Location:
chromosome: 20
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (36395663..36416890, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (36493387..36514011, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene cornichon family AMPA receptor auxiliary protein 3 Neighboring gene si:dkey-1j5.4 Neighboring gene ENAH actin regulator Neighboring gene golgin subfamily A member 6-like protein 25 Neighboring gene golgin subfamily A member 6-like protein 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions. Isiaku AI, et al. Dis Model Mech, 2021 Jul 1. PMID 34296745, Free PMC Article
  2. Structural and functional characterization of the zebrafish lamin B receptor. Schild-Prüfert K, et al. Eur J Cell Biol, 2006 Aug. PMID 16759737
  3. Effects of maternal cadmium exposure on female reproductive functions, gamete quality, and offspring development in zebrafish (Danio rerio). Wu SM, et al. Arch Environ Contam Toxicol, 2013 Oct. PMID 23644582
  4. Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. Xing L, et al. J Biol Chem, 2022 Oct. PMID 36063998, Free PMC Article
  5. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Yin HM, et al. Sci Adv, 2020 May. PMID 32494702, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain.
    Title: Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain.
  2. Data indicate that the LBR of zebrafish and mammals are both required for correct development of embryos.
    Title: Structural and functional characterization of the zebrafish lamin B receptor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables delta14-sterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta14-sterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
delta(14)-sterol reductase LBR
NP_001002720.1
XP_021324046.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002720.1 → NP_001002720.1  delta(14)-sterol reductase LBR

    See identical proteins and their annotated locations for NP_001002720.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075756
    UniProtKB/TrEMBL
    Q6DI34
    Related
    ENSDARP00000015055.6, ENSDART00000019145.8
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:206 → 619
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    36395663..36416890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468371.2 → XP_021324046.1  delta(14)-sterol reductase LBR isoform X1

    UniProtKB/TrEMBL
    A0A8M9PP65
    Related
    ENSDARP00000070893.5, ENSDART00000076419.5
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:206 → 619
    PEMT; Phospholipid methyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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