ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppm1gprovided by ZNC
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1Gprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030425-4
See related: Ensembl:ENSDARG00000075559 AllianceGenome:ZFIN:ZDB-GENE-030425-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb167; wu:fb37b10; wu:fe01e01
Summary: Predicted to enable metal ion binding activity and protein serine/threonine phosphatase activity. Acts upstream of or within central nervous system development. Predicted to be active in nucleoplasm. Is expressed in several structures, including nervous system; neural tube; pectoral fin bud; pectoral fin musculature; and pharyngeal arch. Orthologous to human PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (6188759..6205567)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (6060299..6077114)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear phosphatase PPM1G in cellular survival and neural development.
Title: Nuclear phosphatase PPM1G in cellular survival and neural development.
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing PP1 from binding Axin
Title: Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

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General gene information

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Markers

fe01e01.x1 (e-PCR)
- UniSTS:195908

fb37b10.x1 (e-PCR)
- UniSTS:203152

fi82b06.x1 (e-PCR)
- UniSTS:198074

fb37b10 (e-PCR)
- UniSTS:187123

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cation binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 1G

NP_958896.1

EC 3.1.3.16

XP_005169569.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201488.1 → NP_958896.1 protein phosphatase 1G

See identical proteins and their annotated locations for NP_958896.1

Status: PROVISIONAL

Source sequence(s)

BC052132

UniProtKB/TrEMBL

Q7ZTW5

Conserved Domains (2) summary

smart00332
Location:24 → 109

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

pfam00481
Location:324 → 486

PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

6188759..6205567

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005169512.5 → XP_005169569.1 protein phosphatase 1G isoform X1

UniProtKB/TrEMBL

A0A8M2BGW3, F1QJE5

Related

ENSDARP00000102878.2, ENSDART00000109665.3

Conserved Domains (2) summary

smart00332
Location:24 → 109

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

cd00143
Location:323 → 502

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...