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trpn1 transient receptor potential cation channel, subfamily N, member 1 [ Danio rerio (zebrafish) ]

Gene ID: 368273, updated on 2-Nov-2024

Summary

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Official Symbol
trpn1provided by ZNC
Official Full Name
transient receptor potential cation channel, subfamily N, member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030728-7
See related
AllianceGenome:ZFIN:ZDB-GENE-030728-7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nompC
Summary
Predicted to enable mechanosensitive monoatomic ion channel activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound. Predicted to be located in membrane. Is expressed in integument. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See trpn1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (1435878..1479738)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (1030813..1076628, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase TRIM39 Neighboring gene bloodthirsty-related gene family, member 29 Neighboring gene G-protein coupled receptor 20 Neighboring gene solute carrier family 45 member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Sidi S, et al. Science, 2003 Jul 4. PMID 12805553
  2. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Jin P, et al. Nature, 2017 Jul 6. PMID 28658211, Free PMC Article
  3. Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells. Shin JB, et al. Proc Natl Acad Sci U S A, 2005 Aug 30. PMID 16116094, Free PMC Article
  4. Auditory input to CNS is acquired coincidentally with development of inner ear after formation of functional afferent pathway in zebrafish. Tanimoto M, et al. J Neurosci, 2009 Mar 4. PMID 19261871, Free PMC Article
  5. Role of TRP Channels in Dinoflagellate Mechanotransduction. Lindström JB, et al. Biol Bull, 2017 Oct. PMID 29373067

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. observations indicate that nompC encodes a vertebrate hair cell mechanotransduction channel
    Title: NompC TRP channel required for vertebrate sensory hair cell mechanotransduction.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables mechanosensitive monoatomic ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel, subfamily N, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183349.1 → NP_899192.1  transient receptor potential cation channel, subfamily N, member 1

    See identical proteins and their annotated locations for NP_899192.1

    Status: PROVISIONAL

    Source sequence(s)
    AY313897
    UniProtKB/TrEMBL
    Q7T1G6
    Conserved Domains (5) summary
    cd00204
    Location:606 → 732
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:1342 → 1480
    Ion_trans; Ion transport protein
    pfam12796
    Location:971 → 1058
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:48 → 101
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:186 → 217
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    1435878..1479738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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