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Vha44 Vacuolar H[+] ATPase 44kD subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36826, updated on 2-Nov-2024

Summary

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Official Symbol
Vha44provided by FlyBase
Official Full Name
Vacuolar H[+] ATPase 44kD subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0287825
Locus tag
Dmel_CG8048
See related
AllianceGenome:FB:FBgn0287825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6072; ATP6V1C; ATP6V1C1; CG8048; Dmel\CG8048; l(2)02836; l(2)02836a; l(2)6072; l(2)SH1339; l(2)SH2 1339; vha44
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including Malpighian tubule; adult head; embryonic/larval midgut primordium; ganglia; and gut section. Used to study cancer. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Vha44 in Genome Data Viewer
Location:
53B5-53C1; 2-79 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16324813..16336637, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12212318..12224142, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene HMG Coenzyme A synthase Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 62kD

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative Experimental Models for Studying Influenza Proteins, Host-Virus Interactions and Anti-Influenza Drugs. Chua SCJH, et al. Pharmaceuticals (Basel), 2019 Sep 30. PMID 31575020, Free PMC Article
  2. Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models. Fan QX, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32572941
  3. V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis. Gleixner EM, et al. Cell Rep, 2014 Jul 10. PMID 24953654
  4. RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism. Laiouar S, et al. Curr Biol, 2020 Apr 6. PMID 32059769
  5. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. Dow JA, et al. J Exp Biol, 1997 Jan. PMID 9050231

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. increased levels of V-ATPase C subunit induce a Eiger/JNK-dependent cell transformation within an epithelial organ that recapitulates early carcinoma stages.
    Title: Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATPase activity, rotational mechanism IC
Inferred by Curator
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IC
Inferred by Curator
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of plasma membrane proton-transporting V-type ATPase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
vacuolar H[+] ATPase 44kD subunit
Names
C subunit
CG8048-PA
CG8048-PB
CG8048-PC
CG8048-PE
CG8048-PF
V-ATPase C subunit
Vha44-PA
Vha44-PB
Vha44-PC
Vha44-PE
Vha44-PF
lethal (2) 02836a
lethal (2) SH1339
vacuolar ATPase C-subunit
vacuolar H+ ATPase 44kD C subunit
vacuolar H[+] ATPase 44 kDa subunit
vacuolar H[+] ATPase 44kD C subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16324813..16336637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144207.2 → NP_001137679.1  vacuolar H[+] ATPase 44kD subunit, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137679.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18365, Q0E956, Q5U1B8, Q869C0, Q95RY7, Q9V7N5, Q9V7N6, Q9V7N7
    UniProtKB/TrEMBL
    B7YZI0
    Conserved Domains (3) summary
    cd14785
    Location:570 → 596
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:547 → 822
    V-ATPase_C; V-ATPase subunit C
    cl15414
    Location:6 → 98
    V-ATPase_C; Subunit C of vacuolar H+-ATPase (V-ATPase)

  2. NM_166163.3 → NP_725564.1  vacuolar H[+] ATPase 44kD subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725564.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V7N5
    Related
    FBpp0086319
    Conserved Domains (2) summary
    cd14785
    Location:57 → 77
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:6 → 428
    V-ATPase_C; V-ATPase subunit C

  3. NM_166164.5 → NP_725565.3  vacuolar H[+] ATPase 44kD subunit, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725565.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18365, Q0E956, Q5U1B8, Q869C0, Q95RY7, Q9V7N5, Q9V7N6, Q9V7N7
    UniProtKB/TrEMBL
    B7YZI0
    Conserved Domains (3) summary
    cd14785
    Location:570 → 596
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:547 → 822
    V-ATPase_C; V-ATPase subunit C
    cl15414
    Location:6 → 98
    V-ATPase_C; Subunit C of vacuolar H+-ATPase (V-ATPase)

  4. NM_057918.5 → NP_477266.1  vacuolar H[+] ATPase 44kD subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477266.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V7N5
    Related
    FBpp0086317
    Conserved Domains (1) summary
    pfam03223
    Location:6 → 374
    V-ATPase_C; V-ATPase subunit C

  5. NM_134313.4 → NP_599140.1  vacuolar H[+] ATPase 44kD subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599140.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V7N5
    Related
    FBpp0086320
    Conserved Domains (1) summary
    pfam03223
    Location:6 → 374
    V-ATPase_C; V-ATPase subunit C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7YZI0 B7YZI0
Q9V7N5.5 Q9V7N5

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