U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mrj mrj [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36797, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mrjprovided by FlyBase
Official Full Name
mrjprovided by FlyBase
Primary source
FLYBASE:FBgn0034091
Locus tag
Dmel_CG8448
See related
AllianceGenome:FB:FBgn0034091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8448; Dmel\CG8448; dmrj; dMRJ; MRJ; mrjA
Summary
Predicted to enable protein folding chaperone; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1 and autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to several human genes including DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mrj in Genome Data Viewer
Location:
52F8-52F11; 2-78 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16203329..16221793, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12090834..12109298, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lipoyltransferase 1 Neighboring gene SH2 ankyrin repeat kinase Neighboring gene transfer RNA:Glutamine-CTG 1-1 Neighboring gene transfer RNA:Glutamic acid-TTC 1-1 Neighboring gene transfer RNA:Glutamic acid-CTC 1-1 Neighboring gene transfer RNA:Glutamic acid-TTC 1-2 Neighboring gene antisense RNA:CR43898 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transferrin 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene. Yamamoto I, et al. Sci Rep, 2018 Jul 26. PMID 30050143, Free PMC Article
  2. A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation. Fayazi Z, et al. Neurobiol Dis, 2006 Nov. PMID 16934481
  3. AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. Liévens JC, et al. Hum Mol Genet, 2008 Mar 15. PMID 18065778
  4. Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy. Li S, et al. Hum Mol Genet, 2016 Mar 1. PMID 26744327, Free PMC Article
  5. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. Lee WS, et al. J Clin Invest, 2022 May 2. PMID 35499073, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
    Title: Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
  2. In the retina and other neurons, transgenic dMRJ suppressed polyQ toxicity and colocalized with its inclusions.
    Title: A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mrj
Names
CG8448-PA
CG8448-PB
CG8448-PC
CG8448-PD
CG8448-PE
CG8448-PF
CG8448-PG
CG8448-PH
mrj-PA
mrj-PB
mrj-PC
mrj-PD
mrj-PE
mrj-PF
mrj-PG
mrj-PH

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16203329..16221793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166155.3 → NP_725544.1  mrj, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JUZ6
    Related
    FBpp0086337
    Conserved Domains (2) summary
    COG0484
    Location:2 → 113
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain

  2. NM_001274093.1 → NP_001261022.1  mrj, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261022.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYF7
    Conserved Domains (2) summary
    COG0484
    Location:2 → 66
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain

  3. NM_166156.4 → NP_725545.2  mrj, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725545.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYF7
    Conserved Domains (2) summary
    COG0484
    Location:2 → 66
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain

  4. NM_166153.3 → NP_725542.1  mrj, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JUZ6
    Related
    FBpp0086338
    Conserved Domains (2) summary
    COG0484
    Location:2 → 113
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain

  5. NM_001259435.2 → NP_001246364.1  mrj, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246364.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYF7
    Conserved Domains (2) summary
    COG0484
    Location:2 → 66
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain

  6. NM_166154.3 → NP_725543.1  mrj, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JUZ6
    Related
    FBpp0086339
    Conserved Domains (2) summary
    COG0484
    Location:2 → 113
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain

  7. NM_166152.3 → NP_725541.1  mrj, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725541.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JUZ6
    Related
    FBpp0086340
    Conserved Domains (2) summary
    COG0484
    Location:2 → 113
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain

  8. NM_001259434.2 → NP_001246363.1  mrj, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246363.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHG9
    Conserved Domains (1) summary
    PRK14294
    Location:9 → 66
    PRK14294; chaperone protein DnaJ; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYF7 A8DYF7
A8WHG9 A8WHG9
Q7JUZ6 Q7JUZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools