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Asph Aspartyl beta-hydroxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36778, updated on 14-Nov-2024

Summary

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Official Symbol
Asphprovided by FlyBase
Official Full Name
Aspartyl beta-hydroxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034075
Locus tag
Dmel_CG8421
See related
AllianceGenome:FB:FBgn0034075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BAH/humbug; CG18658; CG8421; Dmel\CG8421
Summary
Predicted to enable peptidyl-aspartic acid 3-dioxygenase activity. Predicted to be involved in regulation of cytosolic calcium ion concentration. Located in endomembrane system. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; larval somatic muscle cell; and mesoderm. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human ASPH (aspartate beta-hydroxylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Asph in Genome Data Viewer
Location:
52E5-52E5; 2-77 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16110331..16116996)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11997836..12004501)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rho1 Neighboring gene Ras-related protein interacting with calmodulin Neighboring gene Juvenile hormone esterase duplication Neighboring gene Juvenile hormone esterase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin. Dinchuk JE, et al. J Biol Chem, 2000 Dec 15. PMID 10956665
  2. Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo. Crone EJ, et al. Insect Biochem Mol Biol, 2007 Jun. PMID 17517331
  3. Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models. Yusuff T, et al. Curr Opin Genet Dev, 2021 Jun. PMID 33812298, Free PMC Article
  4. Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in Insects. Knudsen KE, et al. G3 (Bethesda), 2020 Apr 9. PMID 32019873, Free PMC Article
  5. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidyl-aspartic acid 3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-aspartic acid 3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-aspartic acid hydroxylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aspartyl beta-hydroxylase
Names
Asph-PA
Asph-PB
Asph-PG
Asph-PH
Asph-PI
Asph-PJ
Asph-PK
Asph-PL
CG8421-PA
CG8421-PB
CG8421-PG
CG8421-PH
CG8421-PI
CG8421-PJ
CG8421-PK
CG8421-PL
NP_001246357.1
NP_001246358.1
NP_001246359.1
NP_001261020.1
NP_523757.1
NP_725525.1
NP_725526.1
NP_788365.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16110331..16116996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274091.1 → NP_001261020.1  aspartyl beta-hydroxylase, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261020.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFS5
    Conserved Domains (3) summary
    COG0457
    Location:610 → 854
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:684 → 714
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:826 → 977
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  2. NM_001259429.2 → NP_001246358.1  aspartyl beta-hydroxylase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246358.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K884, Q95S93

  3. NM_001259430.2 → NP_001246359.1  aspartyl beta-hydroxylase, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246359.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1Z397

  4. NM_001259428.2 → NP_001246357.1  aspartyl beta-hydroxylase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7C1
    Conserved Domains (3) summary
    COG0457
    Location:422 → 666
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:496 → 526
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:638 → 789
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  5. NM_176185.4 → NP_788365.2  aspartyl beta-hydroxylase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788365.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZJ1, Q95S93

  6. NM_079033.5 → NP_523757.1  aspartyl beta-hydroxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523757.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KHE2
    Related
    FBpp0086358

  7. NM_166140.4 → NP_725525.1  aspartyl beta-hydroxylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725525.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GQ82
    Related
    FBpp0086359
    Conserved Domains (3) summary
    COG0457
    Location:404 → 659
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:478 → 508
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:620 → 771
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

  8. NM_166141.4 → NP_725526.1  aspartyl beta-hydroxylase, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725526.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4J402, Q95S93
    Related
    FBpp0302595
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4J402 A0A0B4J402
A0A0B4K7C1 A0A0B4K7C1
A0A0B4K884 A0A0B4K884
A0A0B4KFS5 A0A0B4KFS5
A4UZJ1 A4UZJ1
D1Z397 D1Z397
Q7KHE2 Q7KHE2
Q86NU6 Q86NU6
Q95S93 Q95S93
Q9GQ82 Q9GQ82

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