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ATPCL ATP citrate lyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36760, updated on 2-Nov-2024

Summary

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Official Symbol
ATPCLprovided by FlyBase
Official Full Name
ATP citrate lyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0020236
Locus tag
Dmel_CG8322
See related
AllianceGenome:FB:FBgn0020236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACL; Acly; anon-WO0140519.179; atpcl; Atpcl; BcDNA:LD21334; CG8322; CS; dATPCL; DmATPCL; Dmel\CG8322; l(2)01466; l(2)k09217; n(2)k09217
Summary
Predicted to enable ATP citrate synthase activity. Involved in acetyl-CoA biosynthetic process and glucose homeostasis. Predicted to be active in cytosol. Is expressed in adult head and adult heart. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See ATPCL in Genome Data Viewer
Location:
52D10-52D12; 2-76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15993531..16001290, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11881036..11888795, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxin 11a/b Neighboring gene uncharacterized protein Neighboring gene Transmembrane protein 131 Neighboring gene Ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis. Di Giorgio ML, et al. Cells, 2020 Jan 14. PMID 31947614, Free PMC Article
  2. Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. Peleg S, et al. EMBO Rep, 2016 Mar. PMID 26781291, Free PMC Article
  3. Depletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells. Morciano P, et al. Front Physiol, 2019. PMID 31019471, Free PMC Article
  4. The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL. Morciano P, et al. Int J Mol Sci, 2021 May 27. PMID 34072207, Free PMC Article
  5. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Sassu ED, et al. Biochem Biophys Res Commun, 2012 Sep 14. PMID 22910416, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP citrate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP citrate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in acetyl-CoA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in citrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP citrate lyase
Names
ATP-citrate lyase
ATPCL-PD
ATPCL-PE
ATPCL-PF
ATPCL-PG
CG8322-PD
CG8322-PE
CG8322-PF
CG8322-PG
NP_001137674.2
NP_001286470.1
NP_523755.2
NP_725514.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15993531..16001290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144202.3 → NP_001137674.2  ATP citrate lyase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137674.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA78, B7YZH5, Q6AWP8, Q7KN85
    Conserved Domains (7) summary
    cd06100
    Location:868 → 1105
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 421
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:503 → 1106
    PLN02522; ATP citrate (pro-S)-lyase
    smart00881
    Location:504 → 613
    CoA_binding; CoA binding domain
    pfam16114
    Location:248 → 423
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:8 → 208
    ATP-grasp_4; ATP-grasp domain
    cl22543
    Location:672 → 796
    Ligase_CoA; CoA-ligase

  2. NM_079031.3 → NP_523755.2  ATP citrate lyase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523755.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA78, B7YZH5, Q6AWP8, Q7KN85
    Conserved Domains (7) summary
    cd06100
    Location:868 → 1105
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 421
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:503 → 1106
    PLN02522; ATP citrate (pro-S)-lyase
    smart00881
    Location:504 → 613
    CoA_binding; CoA binding domain
    pfam16114
    Location:248 → 423
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:8 → 208
    ATP-grasp_4; ATP-grasp domain
    cl22543
    Location:672 → 796
    Ligase_CoA; CoA-ligase

  3. NM_166131.3 → NP_725514.2  ATP citrate lyase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725514.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCF1, Q6AWP8
    Conserved Domains (7) summary
    cd06100
    Location:851 → 1088
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 421
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:486 → 1089
    PLN02522; ATP citrate (pro-S)-lyase
    smart00881
    Location:487 → 596
    CoA_binding; CoA binding domain
    pfam16114
    Location:248 → 423
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:8 → 208
    ATP-grasp_4; ATP-grasp domain
    cl22543
    Location:655 → 779
    Ligase_CoA; CoA-ligase

  4. NM_001299541.1 → NP_001286470.1  ATP citrate lyase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286470.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFH8, Q6AWP8
    Conserved Domains (7) summary
    cd06100
    Location:852 → 1089
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 421
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:487 → 1090
    PLN02522; ATP citrate (pro-S)-lyase
    smart00881
    Location:488 → 597
    CoA_binding; CoA binding domain
    pfam16114
    Location:248 → 423
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:8 → 208
    ATP-grasp_4; ATP-grasp domain
    cl22543
    Location:656 → 780
    Ligase_CoA; CoA-ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFH8 A0A0B4LFH8
E2QCF1 E2QCF1
Q6NR74 Q6NR74
Q7JNC6 Q7JNC6
Q7KN85 Q7KN85

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