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Mgat4a alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A [ Rattus norvegicus (Norway rat) ]

Gene ID: 367252, updated on 28-Oct-2024

Summary

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Official Symbol
Mgat4aprovided by RGD
Official Full Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Aprovided by RGD
Primary source
RGD:1305650
See related
EnsemblRapid:ENSRNOG00000018276 AllianceGenome:RGD:1305650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alanine-glyoxylate transaminase activity; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; and protein homodimerization activity. Predicted to be involved in N-glycan processing; glyoxylate metabolic process; and protein N-linked glycosylation. Predicted to be located in peroxisome. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 166.4), Kidney (RPKM 105.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mgat4a in Genome Data Viewer
Location:
9q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47169229..47282577, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (39673427..39786747, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44033433..44126946, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-4-phosphatase type I A Neighboring gene uncharacterized LOC120094669 Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 inner nuclear membrane RNA binding protein Neighboring gene CRACD like Neighboring gene uncharacterized LOC134480567 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HCV affects K(ATP) channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic β-cells leading to impaired insulin secretion. Niu B, et al. Endocrine, 2024 May. PMID 37962815, Free PMC Article
  2. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. Ide Y, et al. Biochem Biophys Res Commun, 2006 Mar 10. PMID 16434023
  3. Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice. Takamatsu S, et al. Glycobiology, 2010 Jan. PMID 20015870, Free PMC Article
  4. The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. Kurimoto A, et al. J Biol Chem, 2014 Apr 25. PMID 24619415, Free PMC Article
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HCV affects KATP channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic beta-cells leading to impaired insulin secretion.
    Title: HCV affects K(ATP) channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic β-cells leading to impaired insulin secretion.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine-glyoxylate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in N-glycan processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in glyoxylate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Names
N-acetylglucosaminyltransferase IVa
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa
glcNAc-T IVa
gnT-IVa
mannoside acetylglucosaminyltransferase 4, isoenzyme A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
NP_001012225.1
NP_001153627.1
XP_006244902.1
XP_017452062.1
XP_038939898.1
XP_038939899.1
XP_063123578.1
XP_063123579.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012225.2 → NP_001012225.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2

    See identical proteins and their annotated locations for NP_001012225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal 10-aa segment, compared to isoform 1.
    Source sequence(s)
    BC088215, BM388934, JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5M854
    UniProtKB/TrEMBL
    A6INH4
    Related
    ENSRNOP00000095476.1, ENSRNOT00000097529.2
    Conserved Domains (1) summary
    pfam04666
    Location:94 → 371
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  2. NM_001160155.1 → NP_001153627.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC088215, BM388934, CV115746, JAXUCZ010000009
    UniProtKB/TrEMBL
    A6INH4, F1LMP1
    Related
    ENSRNOP00000024701.5, ENSRNOT00000024701.8
    Conserved Domains (2) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287 → 302
    PGAP4-like; putative TM2 helix [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    47169229..47282577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267508.1 → XP_063123578.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X3

    UniProtKB/Swiss-Prot
    Q5M854

  2. XM_063267509.1 → XP_063123579.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X4

  3. XM_039083970.2 → XP_038939898.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

    UniProtKB/TrEMBL
    A6INH4, F1LMP1
    Related
    ENSRNOP00000101140.1, ENSRNOT00000138713.1
    Conserved Domains (2) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287 → 302
    PGAP4-like; putative TM2 helix [structural motif]

  4. XM_006244840.4 → XP_006244902.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X2

    UniProtKB/TrEMBL
    A6INH4
    Conserved Domains (1) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  5. XM_017596573.3 → XP_017452062.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

    UniProtKB/TrEMBL
    A6INH4, F1LMP1
    Conserved Domains (2) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287 → 302
    PGAP4-like; putative TM2 helix [structural motif]

  6. XM_039083971.2 → XP_038939899.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

    UniProtKB/TrEMBL
    A6INH4, F1LMP1
    Conserved Domains (2) summary
    pfam04666
    Location:103 → 380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287 → 302
    PGAP4-like; putative TM2 helix [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M854.1 GenPept UniProtKB/Swiss-Prot:Q5M854

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