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Khc-73 Kinesin heavy chain 73 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36718, updated on 18-Sep-2024

Summary

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Official Symbol
Khc-73provided by FlyBase
Official Full Name
Kinesin heavy chain 73provided by FlyBase
Primary source
FLYBASE:FBgn0019968
Locus tag
Dmel_CG8183
See related
AllianceGenome:FB:FBgn0019968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe3C9; CG8183; Dmel\CG8183; DmKin73; DmKIN73; DmKlp73; Khc 73; khc-73; KHC-73; khc73; Khc73; KIF 13A; KIF13A/B; Kin73; Kinesin-73; KLP73
Summary
Enables microtubule motor activity and protein homodimerization activity. Involved in establishment of spindle orientation and regulation of synapse structure or activity. Located in early endosome and microtubule plus-end. Colocalizes with astral microtubule. Is expressed in spermatozoon. Orthologous to human KIF13A (kinesin family member 13A) and KIF13B (kinesin family member 13B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Khc-73 in Genome Data Viewer
Location:
52A6-52A10; 2-74 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15515778..15532259, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11403283..11419764, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 52d Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. Huckaba TM, et al. J Biol Chem, 2011 Mar 4. PMID 21169635, Free PMC Article
  2. The mechanisms of fast and slow transport in neurons: identification and characterization of the new kinesin superfamily motors. Hirokawa N. Curr Opin Neurobiol, 1997 Oct. PMID 9384541
  3. miR-92a Suppresses Mushroom Body-Dependent Memory Consolidation in Drosophila. Guven-Ozkan T, et al. eNeuro, 2020 Jul/Aug. PMID 32737186, Free PMC Article
  4. Kinesin-73 in the nervous system of Drosophila embryos. Li HP, et al. Proc Natl Acad Sci U S A, 1997 Feb 18. PMID 9037010, Free PMC Article
  5. The molecular motor toolbox for intracellular transport. Vale RD. Cell, 2003 Feb 21. PMID 12600311

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Khc-73 as a regulator of endosomal traffic at the synapse and modulator of retrograde BMP signaling in motoneurons.
    Title: Kinesin Khc-73/KIF13B modulates retrograde BMP signaling by influencing endosomal dynamics at the Drosophila neuromuscular junction.
  2. The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
    Title: A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle.
  3. the N-terminal half of Khc-73 can undergo a monomer-dimer transition to produce a fast processive motor and that its C-terminal half possesses a specific Rab5-vesicle binding domain
    Title: Kinesin-73 is a processive motor that localizes to Rab5-containing organelles.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin heavy chain 73
Names
CG8183-PA
CG8183-PC
CG8183-PD
CG8183-PE
CG8183-PF
Khc-73-PA
Khc-73-PC
Khc-73-PD
Khc-73-PE
Khc-73-PF
Kinesin-3
Kinesin-73
Kinesin3B
anon-fast-evolving-3C9
kinesin heavy-chain 73

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15515778..15532259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274070.2 → NP_001260999.1  kinesin heavy chain 73, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260999.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG24, O01349
    Conserved Domains (7) summary
    smart00129
    Location:4 → 330
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:417 → 517
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:1 → 330
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1795 → 1859
    CAP_GLY; CAP-Gly domain
    pfam12423
    Location:712 → 757
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1167 → 1223
    DUF3694; Kinesin protein
    pfam16183
    Location:327 → 439
    Kinesin_assoc; Kinesin-associated

  2. NM_176176.3 → NP_788356.2  kinesin heavy chain 73, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788356.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZI0, O01349
    Conserved Domains (7) summary
    smart00129
    Location:6 → 359
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:446 → 546
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 359
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1786 → 1850
    CAP_GLY; CAP-Gly domain
    pfam12423
    Location:741 → 786
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1196 → 1252
    DUF3694; Kinesin protein
    pfam16183
    Location:356 → 468
    Kinesin_assoc; Kinesin-associated

  3. NM_001274071.2 → NP_001261000.1  kinesin heavy chain 73, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261000.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFR5, O01349
    Conserved Domains (7) summary
    smart00129
    Location:6 → 359
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:446 → 546
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 359
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1786 → 1850
    CAP_GLY; CAP-Gly domain
    pfam12423
    Location:741 → 786
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1196 → 1252
    DUF3694; Kinesin protein
    pfam16183
    Location:356 → 468
    Kinesin_assoc; Kinesin-associated

  4. NM_001299533.1 → NP_001286462.1  kinesin heavy chain 73, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286462.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGK5, O01349
    Conserved Domains (7) summary
    smart00129
    Location:6 → 359
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:446 → 546
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 359
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1800 → 1864
    CAP_GLY; CAP-Gly domain
    pfam12423
    Location:741 → 800
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1210 → 1266
    DUF3694; Kinesin protein
    pfam16183
    Location:356 → 468
    Kinesin_assoc; Kinesin-associated

  5. NM_135357.5 → NP_609201.3  kinesin heavy chain 73, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609201.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA18, O01349
    Related
    FBpp0086490
    Conserved Domains (7) summary
    smart00129
    Location:6 → 359
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:446 → 546
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 359
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1808 → 1872
    CAP_GLY; CAP-Gly domain
    pfam12423
    Location:741 → 800
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1210 → 1266
    DUF3694; Kinesin protein
    pfam16183
    Location:356 → 468
    Kinesin_assoc; Kinesin-associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFR5 A0A0B4KFR5
A0A0B4KG24 A0A0B4KG24
A0A0B4LGK5 A0A0B4LGK5
A1ZA18 A1ZA18
A4UZI0 A4UZI0
O01349 O01349

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