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Pgant1 Polypeptide N-Acetylgalactosaminyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36717, updated on 18-Sep-2024

Summary

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Official Symbol
Pgant1provided by FlyBase
Official Full Name
Polypeptide N-Acetylgalactosaminyltransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0034025
Locus tag
Dmel_CG8182
See related
AllianceGenome:FB:FBgn0034025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8182; Dmel\CG8182; GalNAc-T1; pgant1
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Predicted to be active in Golgi apparatus. Is expressed in several structures, including early extended germ band embryo; embryonic/larval digestive system; embryonic/larval tracheal system; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POC1B-GALNT4 (POC1B-GALNT4 readthrough); GALNT12 (polypeptide N-acetylgalactosaminyltransferase 12); and GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pgant1 in Genome Data Viewer
Location:
52A6-52A6; 2-74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15511710..15515597)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11399215..11403102)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 52c Neighboring gene Ionotropic receptor 52d Neighboring gene Kinesin heavy chain 73 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
  2. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714
  3. Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. Tran DT, et al. J Biol Chem, 2012 Feb 17. PMID 22157008, Free PMC Article
  4. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. Zhang L, et al. J Biol Chem, 2010 Nov 5. PMID 20807760, Free PMC Article
  5. An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand. Zhang L, et al. J Biol Chem, 2010 Jun 18. PMID 20371600, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi stack NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
polypeptide N-Acetylgalactosaminyltransferase 1
Names
CG8182-PA
CG8182-PB
CG8182-PC
GalNAc-T1
N-acetylgalactosaminyltransferase
Pgant1-PA
Pgant1-PB
Pgant1-PC
polypeptide GalNAc transferase 1
NP_001286461.1
NP_611043.1
NP_725472.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15511710..15515597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137199.3 → NP_611043.1  polypeptide N-Acetylgalactosaminyltransferase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611043.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E964, Q6WV20, Q9V7C8
    Related
    FBpp0086464
    Conserved Domains (4) summary
    cd02510
    Location:152 → 461
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:147 → 426
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:481 → 599
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:474 → 597
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_166099.2 → NP_725472.1  polypeptide N-Acetylgalactosaminyltransferase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725472.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E964, Q6WV20, Q9V7C8
    Related
    FBpp0086465
    Conserved Domains (4) summary
    cd02510
    Location:152 → 461
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:147 → 426
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:481 → 599
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:474 → 597
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. NM_001299532.1 → NP_001286461.1  polypeptide N-Acetylgalactosaminyltransferase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286461.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFI4
    Conserved Domains (3) summary
    cd02510
    Location:4 → 244
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:264 → 382
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:257 → 380
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFI4 A0A0B4LFI4
Q6WV20.2 Q6WV20

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