scb scab [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: scbprovided by FlyBase
Official Full Name: scabprovided by FlyBase
Primary source: FLYBASE:FBgn0286785
Locus tag: Dmel_CG8095
See related: AllianceGenome:FB:FBgn0286785
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: &agr-PS3; alpha-PS3; alphaInt3; alphaPS3; alpha[[PS3]]; aPS3; beta[[PS3]; CG8095; CT21280; CT36929; Dm0620; Dmel\CG8095; E(Sev-CycE)E93; E(sev-cycE)[e93]; integrin; Integrin alpha PS3; ITA3; ItgaPS3; l(2)01288; l(2)51Ea; PS3; vol; Vol
Summary: Enables protein heterodimerization activity. Involved in several processes, including behavioral response to ethanol; dorsal trunk growth, open tracheal system; and heart development. Located in apical plasma membrane; basal plasma membrane; and cytoplasm. Part of integrin complex. Is expressed in several structures, including Kenyon cell; epithelium; follicle cell; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to several human genes including ITGA9 (integrin subunit alpha 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 51E10-51E11; 2-74 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15248784..15258498)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11136289..11146003)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the integrin heterodimer alphaPS3/betaPS becomes apically enriched and is required for engulfment by the epithelial follicle cells of the Drosophila ovary.
Title: Polarization of the epithelial layer and apical localization of integrins are required for engulfment of apoptotic cells in the Drosophila ovary.
Study presents evidence that alphaPS2 and alphaPS3 integrin have different and specific functions in the development of retinal glia
Title: Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions.
that integrin alphaPS3/betanu serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes.
Title: Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila.
We identify a role for the alphaPS3, betaPS1 Integrin dimer in both the early establishment of the apical, pre-luminal domain, as well as a requirement upon Robo for maintained apicalisation of proteins required for lumen formation.
Title: Integrins are required for cardioblast polarisation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2177 (e-PCR)
- UniSTS:26436

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 15258246-15258290 mobile_element_type = transposon:INE-1{}5684

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	TAS Traceable Author Statement more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal trunk growth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in larval heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	TAS Traceable Author Statement more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	TAS Traceable Author Statement more info	PubMed
involved_in wound healing	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info
part_of integrin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: scab

Names: CG8095-PA; CG8095-PB; aVolado; alpha Position-Specific antigen 3; alpha3 integrin subunit; alphaPS3 integrin; alphaPS3 subunit; beta[[PS3]]integrin; complementation group 2.11; integrin; integrin alpha PS3; integrin alphaPS3 subunit; laminin receptor integrin alpha-PS3; lethal (2) 51Ea; scb-PA; scb-PB; volado

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15248784..15258498

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079026.3 → NP_523750.2 scab, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523750.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O44386, O44387, O46186, Q58CK3, Q6AWK3, Q9V7A3

Related

FBpp0086501

Conserved Domains (3) summary

smart00191
Location:409 → 459

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam01839
Location:350 → 388

FG-GAP; FG-GAP repeat

pfam08441
Location:507 → 829

Integrin_alpha2; Integrin alpha
NM_166083.2 → NP_725445.1 scab, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725445.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44386

Related

FBpp0086502

Conserved Domains (3) summary

smart00191
Location:409 → 459

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam01839
Location:350 → 388

FG-GAP; FG-GAP repeat

pfam08441
Location:507 → 829

Integrin_alpha2; Integrin alpha