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ND-B15 NADH dehydrogenase (ubiquinone) B15 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36640, updated on 18-Sep-2024

Summary

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Official Symbol
ND-B15provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) B15 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0033961
Locus tag
Dmel_CG12859
See related
AllianceGenome:FB:FBgn0033961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe3B12; CG 12859; CG12859; Dmel\CG12859; dNDUFB4; NB5M; NDUFB4; Q6IDF5
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ND-B15 in Genome Data Viewer
Location:
51C2-51C2; 2-72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14756516..14757072)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10644021..10644577)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Regulatory particle non-ATPase 6 Neighboring gene uncharacterized protein Neighboring gene aveugle Neighboring gene TRAPP subunit 31 Neighboring gene uncharacterized protein Neighboring gene Sprouty-related protein with EVH-1 domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. Ebanks B, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769041, Free PMC Article
  2. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
  3. Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Murari A, et al. Cell Rep, 2023 Aug 29. PMID 37516961, Free PMC Article
  4. Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. Padavannil A, et al. Elife, 2023 Mar 23. PMID 36952377, Free PMC Article
  5. Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster. Agip AA, et al. Elife, 2023 Jan 9. PMID 36622099, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) B15 subunit
Names
CG12859-PA
NADH ubiquinone oxidoreductase B15
NADH-ubiquinone oxidoreductase B15 subunit
NADH:ubiquinone oxidoreductase B15 subunit
ND-B15-PA
anon-fast-evolving-3B12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14756516..14757072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137141.5 → NP_610985.1  NADH dehydrogenase (ubiquinone) B15 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610985.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6IDF5
    Related
    FBpp0086570
    Conserved Domains (1) summary
    pfam07225
    Location:21 → 111
    NDUF_B4; NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IDF5 Q6IDF5

Gene LinkOut

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