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AttB Attacin-B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36637, updated on 18-Sep-2024

Summary

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Official Symbol
AttBprovided by FlyBase
Official Full Name
Attacin-Bprovided by FlyBase
Primary source
FLYBASE:FBgn0041581
Locus tag
Dmel_CG18372
See related
AllianceGenome:FB:FBgn0041581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
att; Att; Att B; att B1; attacin b; Attacin B; attB; Attb; attB1; AttB1; AttB2; AttBn; CG18372; Dmel\CG18372
Summary
Involved in antibacterial humoral response; defense response to Gram-positive bacterium; and defense response to insect. Located in extracellular space. Is expressed in embryonic/larval hemolymph. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AttB in Genome Data Viewer
Location:
51C1-51C1; 2-72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14749223..14750165)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10636728..10637670)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Drosocin Neighboring gene Attacin-A Neighboring gene Regulatory particle non-ATPase 6 Neighboring gene aveugle Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of aminergic signaling on the humoral innate immunity response of Drosophila. Cattabriga G, et al. Front Physiol, 2023. PMID 37693001, Free PMC Article
  2. Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption. Dissel S, et al. Brain Behav Immun, 2015 Jul. PMID 25451614, Free PMC Article
  3. Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging. Wang M, et al. Aging (Albany NY), 2020 Jan 6. PMID 31907335, Free PMC Article
  4. Venom components of Asobara japonica impair cellular immune responses of host Drosophila melanogaster. Furihata SX, et al. Arch Insect Biochem Physiol, 2013 Jun. PMID 23606512
  5. Evidence for recurrent paralogous gene conversion and exceptional allelic divergence in the Attacin genes of Drosophila melanogaster. Lazzaro BP, et al. Genetics, 2001 Oct. PMID 11606542, Free PMC Article

See all (223) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in antibacterial humoral response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in antibacterial humoral response ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to insect IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in humoral immune response IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Attacin-B
Names
AttB-PA
AttB-PB
Attacin-B precursor
AttacinB
CG18372-PA
CG18372-PB
attacin
attacin (B)
attacin B
attacin B1
attacin-B
attackin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14749223..14750165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169681.2 → NP_001163152.1  Attacin-B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163152.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95NV4, Q95U95, Q95U96, Q9V751
    UniProtKB/TrEMBL
    E1JH67
    Conserved Domains (2) summary
    pfam03768
    Location:31 → 96
    Attacin_N; Attacin, N-terminal region
    pfam03769
    Location:98 → 217
    Attacin_C; Attacin, C-terminal region

  2. NM_079022.3 → NP_523746.1  Attacin-B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523746.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95NV4, Q95U95, Q95U96, Q9V751
    UniProtKB/TrEMBL
    E1JH67
    Conserved Domains (2) summary
    pfam03768
    Location:31 → 96
    Attacin_N; Attacin, N-terminal region
    pfam03769
    Location:98 → 217
    Attacin_C; Attacin, C-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JH67 E1JH67
Q9V751.2 Q9V751

Gene LinkOut

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