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mspo M-spondin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36632, updated on 18-Sep-2024

Summary

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Official Symbol
mspoprovided by FlyBase
Official Full Name
M-spondinprovided by FlyBase
Primary source
FLYBASE:FBgn0020269
Locus tag
Dmel_CG10145
See related
AllianceGenome:FB:FBgn0020269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10145; CT28539; Dmel\CG10145; m-spo; Mspo
Summary
Involved in regulation of myoblast fusion. Located in collagen-containing extracellular matrix. Is expressed in several structures, including adult external thorax; anlage in statu nascendi; embryonic/larval circulatory system; embryonic/larval muscle system; and presumptive embryonic/larval nervous system. Orthologous to human SPON2 (spondin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See mspo in Genome Data Viewer
Location:
51B9-51C1; 2-72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14671396..14713622, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10558901..10601127, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tarag Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene jet fuel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. M-spondin, a novel ECM protein highly homologous to vertebrate F-spondin, is localized at the muscle attachment sites in the Drosophila embryo. Umemiya T, et al. Dev Biol, 1997 Jun 15. PMID 9205137
  2. Characterization and mutant analysis of the Drosophila sema 5c gene. Bahri SM, et al. Dev Dyn, 2001 Jul. PMID 11458392
  3. A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells. Mollereau B, et al. Mech Dev, 2000 May. PMID 10781948
  4. Dynamics of transcriptional (re)-programming of syncytial nuclei in developing muscles. Bataillé L, et al. BMC Biol, 2017 Jun 9. PMID 28599653, Free PMC Article
  5. Downstream of identity genes: muscle-type-specific regulation of the fusion process. Bataillé L, et al. Dev Cell, 2010 Aug 17. PMID 20708593, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
M-spondin
Names
CG10145-PA
CG10145-PB
m-spondin
mspo-PA
mspo-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14671396..14713622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299498.1 → NP_001286427.1  M-spondin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02029, Q7JY80
    Conserved Domains (2) summary
    smart00209
    Location:537 → 588
    TSP1; Thrombospondin type 1 repeats
    pfam06468
    Location:120 → 363
    Spond_N; Spondin_N

  2. NM_166063.2 → NP_725407.1  M-spondin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725407.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02029, Q7JY80
    Related
    FBpp0086606
    Conserved Domains (2) summary
    smart00209
    Location:537 → 588
    TSP1; Thrombospondin type 1 repeats
    pfam06468
    Location:120 → 363
    Spond_N; Spondin_N
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02029 O02029
Q7JY80 Q7JY80

Gene LinkOut

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