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Catsper2 cation channel, sperm associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366174, updated on 10-Oct-2024

Summary

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Official Symbol
Catsper2provided by RGD
Official Full Name
cation channel, sperm associated 2provided by RGD
Primary source
RGD:1307620
See related
EnsemblRapid:ENSRNOG00000023064 AllianceGenome:RGD:1307620
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium activated cation channel activity; calcium channel activity; and voltage-gated ion channel activity. Predicted to be involved in fertilization; flagellated sperm motility; and sperm capacitation. Predicted to be located in sperm flagellum. Predicted to be part of CatSper complex. Orthologous to human CATSPER2 (cation channel sperm associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 133.8), Kidney (RPKM 16.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Catsper2 in Genome Data Viewer
Location:
3q35
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128822387..128842501, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108368654..108389380, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113357361..113379498, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene creatine kinase, mitochondrial 1 Neighboring gene stereocilin Neighboring gene protein disulfide isomerase family A, member 3 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U105C small nucleolar

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of fertilization in male rats by CatSper2 knockdown. Zhang Z, et al. Asian J Androl, 2012 Mar. PMID 22002435, Free PMC Article
  2. Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Quill TA, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657366, Free PMC Article
  3. The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats. Ameli M, et al. Mol Reprod Dev, 2019 Jun. PMID 31041823
  4. Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm. Marquez B, et al. Dev Biol, 2007 Mar 1. PMID 17174296, Free PMC Article
  5. A voltage-gated ion channel expressed specifically in spermatozoa. Quill TA, et al. Proc Natl Acad Sci U S A, 2001 Oct 23. PMID 11675491, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
    Title: The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
  2. It is feasible to achieve male contraception by silencing the expression of CatSper2, the key protein involved in sperm hyperactivation.
    Title: Regulation of fertilization in male rats by CatSper2 knockdown.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sperm capacitation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CatSper complex IEA
Inferred from Electronic Annotation
more info
  
part_of CatSper complex ISO
Inferred from Sequence Orthology
more info
  
part_of CatSper complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cation channel sperm-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012220.1 → NP_001012220.1  cation channel sperm-associated protein 2

    See identical proteins and their annotated locations for NP_001012220.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079422
    UniProtKB/Swiss-Prot
    Q6AXP6
    UniProtKB/TrEMBL
    A0A8I5ZML1, A6HPN9
    Related
    ENSRNOP00000038712.3, ENSRNOT00000030019.5
    Conserved Domains (2) summary
    pfam00183
    Location:419 → 463
    HSP90; Hsp90 protein
    pfam00520
    Location:138 → 348
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128822387..128842501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591949.3 → XP_017447438.1  cation channel sperm-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AXP6
    UniProtKB/TrEMBL
    A0A8I5ZML1, A6HPN9
    Conserved Domains (2) summary
    pfam00183
    Location:419 → 463
    HSP90; Hsp90 protein
    pfam00520
    Location:138 → 348
    Ion_trans; Ion transport protein

  2. XM_063284284.1 → XP_063140354.1  cation channel sperm-associated protein 2 isoform X2

    Related
    ENSRNOP00000098911.1, ENSRNOT00000136426.1

  3. XM_008762187.4 → XP_008760409.1  cation channel sperm-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008760409.1

    UniProtKB/Swiss-Prot
    Q6AXP6
    UniProtKB/TrEMBL
    A0A8I5ZML1, A6HPN9
    Conserved Domains (2) summary
    pfam00183
    Location:419 → 463
    HSP90; Hsp90 protein
    pfam00520
    Location:138 → 348
    Ion_trans; Ion transport protein

  4. XM_006234860.4 → XP_006234922.1  cation channel sperm-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZML1
    Conserved Domains (2) summary
    pfam00183
    Location:379 → 423
    HSP90; Hsp90 protein
    pfam00520
    Location:146 → 308
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXP6.1 GenPept UniProtKB/Swiss-Prot:Q6AXP6

Gene LinkOut

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